Which bioequivalence study for a racemic drug? Application to milnacipran

Milnacipran, a new non tricyclic antidepressant drug, is a racemic mixture (F2207) composed of two enantiomers: F2695 and F2696, both demonstrated to be active. A randomized open label, single-dose latin square study was undertaken in 24 healthy volunteers to compare, based on racemate data, the rel...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1998-04, Vol.23 (2), p.166-171
Hauptverfasser:	DEPREZ, D, CHASSARD D, D, BAILLE P, P, MIGNOT, A, UNG, H. L, PUOZZO, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antidepressive Agents - pharmacokinetics Area Under Curve Biological and medical sciences Chemistry, Pharmaceutical Cross-Over Studies Cyclopropanes - pharmacokinetics Humans Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Stereoisomerism Therapeutic Equivalency
Online-Zugang:	Volltext
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