Mapping Human Interferon-alpha (IFN-α2) Binding Determinants of the Type I Interferon Receptor Subunit IFNAR-1 with Human/Bovine IFNAR-1 Chimeras

Type I interferons bind to a common receptor (IFNAR), composed of two transmembrane polypeptides, IFNAR-1 and IFNAR-2. Although human IFNAR-1 has a weak intrinsic affinity for human Type I interferons (IFNs), bovine IFNAR-1 binds human Type I IFNs with moderate (nM) affinity, and can be conveniently...

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Veröffentlicht in:	Biochemistry (Easton) 1998-09, Vol.37 (37), p.13003-13010
Hauptverfasser:	Goldman, Lisa A, Cutrone, Elizabeth Cali, Dang, Anju, Hao, Xiaoming, Lim, Jin-kyu, Langer, Jerome A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle COS Cells Genetic Vectors - chemical synthesis Genetic Vectors - metabolism Humans Interferon-alpha - biosynthesis Interferon-alpha - genetics Interferon-alpha - metabolism Ligands Membrane Proteins Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Mapping - methods Protein Binding Protein Structure, Tertiary Receptor, Interferon alpha-beta Receptors, Interferon - genetics Receptors, Interferon - metabolism Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - metabolism
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