Polymeric micelles for drug delivery: solubilization and haemolytic activity of amphotericin B

Polymeric micelles may serve as nanoscopic, long-circulating carriers of hydrophobic drugs. In this study, we have researched the solubilization of amphotericin B (AmB), an antifungal drug, by micelles of poly(ethylene oxide)-block-poly(β benzyl- l-aspartate) (PEO-PBLA), the properties of the AmB-lo...

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Veröffentlicht in:	Journal of controlled release 1998-04, Vol.53 (1), p.131-136
Hauptverfasser:	Yu, B.G, Okano, T, Kataoka, K, Kwon, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B Amphotericin B - administration & dosage Amphotericin B - chemistry Amphotericin B - pharmacology Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - pharmacology Biological and medical sciences Drug Carriers Excipients General pharmacology Haemolysis Hemolysis - drug effects Medical sciences Micelles Microscopy, Electron PEO-PBLA micelles Peptides Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols Size distribution Solubility TEM
Online-Zugang:	Volltext
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