Dietary Fish Oils Modify the Assembly of VLDL and Expression of the LDL Receptor in Rabbit Liver
Supplementation of the diet of rabbits with fish oil or sunflower oil resulted in significant changes in the lipoproteins and lipids in serum. Compared with chow-fed rabbits, dietary fish oils decreased very low density lipoprotein (VLDL), increased low density lipoprotein (LDL), and shifted the pea...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1998-09, Vol.18 (9), p.1490-1497 |
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| creator | Wilkinson, Jane Higgins, Joan A Fitzsimmons, Colin Bowyer, David E |
| description | Supplementation of the diet of rabbits with fish oil or sunflower oil resulted in significant changes in the lipoproteins and lipids in serum. Compared with chow-fed rabbits, dietary fish oils decreased very low density lipoprotein (VLDL), increased low density lipoprotein (LDL), and shifted the peak of the LDL to denser fractions, whereas sunflower oil increased high density lipoprotein and shifted LDL to the lighter fractions. The amount of LDL receptors in fish oil-fed rabbit liver decreased by >70% while there was only a small fall in these levels in sunflower oil-fed rabbit liver. The concentrations of apolipoprotein (apo) B in the subcellular organelles of the secretory compartment (rough and smooth endoplasmic reticula and Golgi fractions) were also changed by dietary lipids. In both sunflower oil- and fish oil-fed liver, apo B was increased in the lumen of the rough endoplasmic reticulum compared with fractions from chow-fed rabbit liver. The apo B in the trans-Golgi lumen from fish oil-fed livers was reduced and occurred in particles of d[approximate]1.21 g/mL. In contrast, apo B in the trans-Golgi lumen from livers of sunflower oil-fed rabbits was increased and occurred in particles of d |
| doi_str_mv | 10.1161/01.ATV.18.9.1490 |
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Compared with chow-fed rabbits, dietary fish oils decreased very low density lipoprotein (VLDL), increased low density lipoprotein (LDL), and shifted the peak of the LDL to denser fractions, whereas sunflower oil increased high density lipoprotein and shifted LDL to the lighter fractions. The amount of LDL receptors in fish oil-fed rabbit liver decreased by >70% while there was only a small fall in these levels in sunflower oil-fed rabbit liver. The concentrations of apolipoprotein (apo) B in the subcellular organelles of the secretory compartment (rough and smooth endoplasmic reticula and Golgi fractions) were also changed by dietary lipids. In both sunflower oil- and fish oil-fed liver, apo B was increased in the lumen of the rough endoplasmic reticulum compared with fractions from chow-fed rabbit liver. The apo B in the trans-Golgi lumen from fish oil-fed livers was reduced and occurred in particles of d[approximate]1.21 g/mL. In contrast, apo B in the trans-Golgi lumen from livers of sunflower oil-fed rabbits was increased and occurred in particles of d<1.21 g/mL. These results suggests that feeding of fish oils causes an interruption in the intracellular transfer of apo B and hence assembly of VLDL. This leads to an enrichment of the rough endoplasmic reticulum membranes with cholesterol, thus downregulating the expression of the LDL receptor. (Arterioscler Thromb Vasc Biol. 1998;18:1490-1497.)</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/01.ATV.18.9.1490</identifier><identifier>PMID: 9743239</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Animals ; Apolipoproteins B - metabolism ; Biological and medical sciences ; Cytoplasmic Granules - metabolism ; Dietary Fats, Unsaturated - pharmacology ; Endoplasmic Reticulum, Rough - ultrastructure ; Endoplasmic Reticulum, Smooth - ultrastructure ; Fish Oils - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Golgi Apparatus - ultrastructure ; Lipids - analysis ; Lipids - blood ; Lipids. Glycolipids ; Lipoproteins, LDL - blood ; Lipoproteins, VLDL - blood ; Lipoproteins, VLDL - metabolism ; Liver - metabolism ; Liver - ultrastructure ; Metabolisms and neurohumoral controls ; Microsomes - chemistry ; Plant Oils - administration & dosage ; Rabbits ; Receptors, LDL - genetics ; Subcellular Fractions - metabolism ; Sunflower Oil ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 1998-09, Vol.18 (9), p.1490-1497</ispartof><rights>1998 American Heart Association, Inc.</rights><rights>1998 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Sep 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4718-1ec6f83631f2c5b870dc58c8a902959c86049e37b5ed74a9d5aaf8a89018b4293</citedby><cites>FETCH-LOGICAL-c4718-1ec6f83631f2c5b870dc58c8a902959c86049e37b5ed74a9d5aaf8a89018b4293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2387897$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9743239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilkinson, Jane</creatorcontrib><creatorcontrib>Higgins, Joan A</creatorcontrib><creatorcontrib>Fitzsimmons, Colin</creatorcontrib><creatorcontrib>Bowyer, David E</creatorcontrib><title>Dietary Fish Oils Modify the Assembly of VLDL and Expression of the LDL Receptor in Rabbit Liver</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>Supplementation of the diet of rabbits with fish oil or sunflower oil resulted in significant changes in the lipoproteins and lipids in serum. Compared with chow-fed rabbits, dietary fish oils decreased very low density lipoprotein (VLDL), increased low density lipoprotein (LDL), and shifted the peak of the LDL to denser fractions, whereas sunflower oil increased high density lipoprotein and shifted LDL to the lighter fractions. The amount of LDL receptors in fish oil-fed rabbit liver decreased by >70% while there was only a small fall in these levels in sunflower oil-fed rabbit liver. The concentrations of apolipoprotein (apo) B in the subcellular organelles of the secretory compartment (rough and smooth endoplasmic reticula and Golgi fractions) were also changed by dietary lipids. In both sunflower oil- and fish oil-fed liver, apo B was increased in the lumen of the rough endoplasmic reticulum compared with fractions from chow-fed rabbit liver. The apo B in the trans-Golgi lumen from fish oil-fed livers was reduced and occurred in particles of d[approximate]1.21 g/mL. In contrast, apo B in the trans-Golgi lumen from livers of sunflower oil-fed rabbits was increased and occurred in particles of d<1.21 g/mL. These results suggests that feeding of fish oils causes an interruption in the intracellular transfer of apo B and hence assembly of VLDL. This leads to an enrichment of the rough endoplasmic reticulum membranes with cholesterol, thus downregulating the expression of the LDL receptor. (Arterioscler Thromb Vasc Biol. 1998;18:1490-1497.)</description><subject>Animals</subject><subject>Apolipoproteins B - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cytoplasmic Granules - metabolism</subject><subject>Dietary Fats, Unsaturated - pharmacology</subject><subject>Endoplasmic Reticulum, Rough - ultrastructure</subject><subject>Endoplasmic Reticulum, Smooth - ultrastructure</subject><subject>Fish Oils - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Golgi Apparatus - ultrastructure</subject><subject>Lipids - analysis</subject><subject>Lipids - blood</subject><subject>Lipids. Glycolipids</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Lipoproteins, VLDL - metabolism</subject><subject>Liver - metabolism</subject><subject>Liver - ultrastructure</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Microsomes - chemistry</subject><subject>Plant Oils - administration & dosage</subject><subject>Rabbits</subject><subject>Receptors, LDL - genetics</subject><subject>Subcellular Fractions - metabolism</subject><subject>Sunflower Oil</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1r3DAQhk1pSdMk914KooTe7OrLlua45LPgEghJroosj1mlXnsr2U3331dmlxx6ENLofWYQj7LsM6MFYxX7TlmxengqmC6gYBLou-yYlVzmshLV-3SmCvKykvxj9inGF0qp5JweZUegpOACjrPnS4-TDTty7eOa3Pk-kp9j67sdmdZIVjHipul3ZOzIU31ZEzu05OrvNmCMfhyW6wVbknt0uJ3GQPxA7m3T-InU_g-G0-xDZ_uIZ4f9JHu8vnq4uM3ru5sfF6s6d1IxnTN0VadFJVjHXdloRVtXaqctUA4lOF1RCShUU2KrpIW2tLbTVgNlupEcxEn2bT93G8bfM8bJbHx02Pd2wHGORglgQsECfv0PfBnnMKS3GZ70AK80TRDdQy6MMQbszDb4TfJkGDWLeUOZSeYN0wbMYj61fDnMnZsNtm8NB9UpPz_kNjrbd8EOzsc3jAutNKiEyT32OvYThvirn18xmDXaflqb5QdFRcucAWgKqczTYlr8A_JymEU</recordid><startdate>199809</startdate><enddate>199809</enddate><creator>Wilkinson, Jane</creator><creator>Higgins, Joan A</creator><creator>Fitzsimmons, Colin</creator><creator>Bowyer, David E</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199809</creationdate><title>Dietary Fish Oils Modify the Assembly of VLDL and Expression of the LDL Receptor in Rabbit Liver</title><author>Wilkinson, Jane ; Higgins, Joan A ; Fitzsimmons, Colin ; Bowyer, David E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4718-1ec6f83631f2c5b870dc58c8a902959c86049e37b5ed74a9d5aaf8a89018b4293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Apolipoproteins B - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cytoplasmic Granules - metabolism</topic><topic>Dietary Fats, Unsaturated - pharmacology</topic><topic>Endoplasmic Reticulum, Rough - ultrastructure</topic><topic>Endoplasmic Reticulum, Smooth - ultrastructure</topic><topic>Fish Oils - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Golgi Apparatus - ultrastructure</topic><topic>Lipids - analysis</topic><topic>Lipids - blood</topic><topic>Lipids. Glycolipids</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Lipoproteins, VLDL - metabolism</topic><topic>Liver - metabolism</topic><topic>Liver - ultrastructure</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Microsomes - chemistry</topic><topic>Plant Oils - administration & dosage</topic><topic>Rabbits</topic><topic>Receptors, LDL - genetics</topic><topic>Subcellular Fractions - metabolism</topic><topic>Sunflower Oil</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilkinson, Jane</creatorcontrib><creatorcontrib>Higgins, Joan A</creatorcontrib><creatorcontrib>Fitzsimmons, Colin</creatorcontrib><creatorcontrib>Bowyer, David E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilkinson, Jane</au><au>Higgins, Joan A</au><au>Fitzsimmons, Colin</au><au>Bowyer, David E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Fish Oils Modify the Assembly of VLDL and Expression of the LDL Receptor in Rabbit Liver</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>1998-09</date><risdate>1998</risdate><volume>18</volume><issue>9</issue><spage>1490</spage><epage>1497</epage><pages>1490-1497</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>Supplementation of the diet of rabbits with fish oil or sunflower oil resulted in significant changes in the lipoproteins and lipids in serum. Compared with chow-fed rabbits, dietary fish oils decreased very low density lipoprotein (VLDL), increased low density lipoprotein (LDL), and shifted the peak of the LDL to denser fractions, whereas sunflower oil increased high density lipoprotein and shifted LDL to the lighter fractions. The amount of LDL receptors in fish oil-fed rabbit liver decreased by >70% while there was only a small fall in these levels in sunflower oil-fed rabbit liver. The concentrations of apolipoprotein (apo) B in the subcellular organelles of the secretory compartment (rough and smooth endoplasmic reticula and Golgi fractions) were also changed by dietary lipids. In both sunflower oil- and fish oil-fed liver, apo B was increased in the lumen of the rough endoplasmic reticulum compared with fractions from chow-fed rabbit liver. The apo B in the trans-Golgi lumen from fish oil-fed livers was reduced and occurred in particles of d[approximate]1.21 g/mL. In contrast, apo B in the trans-Golgi lumen from livers of sunflower oil-fed rabbits was increased and occurred in particles of d<1.21 g/mL. These results suggests that feeding of fish oils causes an interruption in the intracellular transfer of apo B and hence assembly of VLDL. This leads to an enrichment of the rough endoplasmic reticulum membranes with cholesterol, thus downregulating the expression of the LDL receptor. (Arterioscler Thromb Vasc Biol. 1998;18:1490-1497.)</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>9743239</pmid><doi>10.1161/01.ATV.18.9.1490</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1079-5642 |
| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 1998-09, Vol.18 (9), p.1490-1497 |
| issn | 1079-5642 1524-4636 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload; Alma/SFX Local Collection |
| subjects | Animals Apolipoproteins B - metabolism Biological and medical sciences Cytoplasmic Granules - metabolism Dietary Fats, Unsaturated - pharmacology Endoplasmic Reticulum, Rough - ultrastructure Endoplasmic Reticulum, Smooth - ultrastructure Fish Oils - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Golgi Apparatus - ultrastructure Lipids - analysis Lipids - blood Lipids. Glycolipids Lipoproteins, LDL - blood Lipoproteins, VLDL - blood Lipoproteins, VLDL - metabolism Liver - metabolism Liver - ultrastructure Metabolisms and neurohumoral controls Microsomes - chemistry Plant Oils - administration & dosage Rabbits Receptors, LDL - genetics Subcellular Fractions - metabolism Sunflower Oil Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Dietary Fish Oils Modify the Assembly of VLDL and Expression of the LDL Receptor in Rabbit Liver |
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