First trimester screening for Down's syndrome using maternal serum PAPP‐A and free β=hCG in combination with fetal nuchal translucency thickness
The aim of this study was to evaluate the potential effectiveness of maternal serum pregnancy‐associated plasma protein A (PAPP‐A) and free β‐hCG in combination with nuchal translucency thickness in first trimester screening for Down's syndrome. Maternal serum levels of PAPP‐A and free β‐hCG we...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 1998-08, Vol.105 (8), p.917-920 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Biagiotti, Roberto Brizn, Laura Periti, Enrico D'Agata, Albertino VanZi, Ermanno Cariati, Ettore |
| description | The aim of this study was to evaluate the potential effectiveness of maternal serum pregnancy‐associated plasma protein A (PAPP‐A) and free β‐hCG in combination with nuchal translucency thickness in first trimester screening for Down's syndrome. Maternal serum levels of PAPP‐A and free β‐hCG were assayed in stored sera from 32 Down's syndrome and 200 unaffected pregnancies. Fetal nuchal translucency was measured by ultrasound at the time of blood sampling. Screening of Down's syndrome using a combination of maternal age, PAPP‐A, free β‐hCG and nuchal translucency would achieve a detection rate of 75.8% for a false positive rate of 5%. |
| doi_str_mv | 10.1111/j.1471-0528.1998.tb10239.x |
| format | Article |
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Maternal serum levels of PAPP‐A and free β‐hCG were assayed in stored sera from 32 Down's syndrome and 200 unaffected pregnancies. Fetal nuchal translucency was measured by ultrasound at the time of blood sampling. Screening of Down's syndrome using a combination of maternal age, PAPP‐A, free β‐hCG and nuchal translucency would achieve a detection rate of 75.8% for a false positive rate of 5%.</description><identifier>ISSN: 1470-0328</identifier><identifier>ISSN: 0306-5456</identifier><identifier>EISSN: 1471-0528</identifier><identifier>EISSN: 1365-215X</identifier><identifier>DOI: 10.1111/j.1471-0528.1998.tb10239.x</identifier><identifier>PMID: 9746387</identifier><identifier>CODEN: BJOGAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Chorionic Gonadotropin - blood ; Down Syndrome - blood ; Down Syndrome - diagnosis ; False Positive Reactions ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Management. Prenatal diagnosis ; Medical sciences ; Neck - embryology ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy-Associated Plasma Protein-A - analysis ; Pregnancy. Fetus. 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Maternal serum levels of PAPP‐A and free β‐hCG were assayed in stored sera from 32 Down's syndrome and 200 unaffected pregnancies. Fetal nuchal translucency was measured by ultrasound at the time of blood sampling. Screening of Down's syndrome using a combination of maternal age, PAPP‐A, free β‐hCG and nuchal translucency would achieve a detection rate of 75.8% for a false positive rate of 5%.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Down Syndrome - blood</subject><subject>Down Syndrome - diagnosis</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Neck - embryology</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy-Associated Plasma Protein-A - analysis</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal Diagnosis - methods</subject><subject>Sensitivity and Specificity</subject><issn>1470-0328</issn><issn>0306-5456</issn><issn>1471-0528</issn><issn>1365-215X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUUuO1DAUjBBoGAaOgGQhxKwS_EknNhJIPQ0zgEaaXsDachybdpM4g5-jnt5xBCRuwkE4BCfBoaPe8zbvWVVlP1dl2TOCC5Lq5bYgZU1yvKC8IELwIjYEUyaKu3vZ6RG6_2_GOWaUP8weAWwxJhXF7CQ7EXVZMV6fZj8vXYCIYnC9gWgCAh2M8c5_QXYI6O2w8-eAYO_bMPQGjTAhvUpMrzoEJow9Wi_X6z_ffyyR8i2ySY5-_3q9WV0h55Ee-sZ5Fd3g0c7FDbImJqEf9Sa1GJSHbtTG6z2KG6e_egPwOHtgVQfmydzPss-X7z6t3ufXN1cfVsvrXJcLXOeVKAXTHCvNm9KWLW8pFpoKRbHFglXctmKxKLVO5wZTQilpG6GI5QnURLGz7MXh3tswfBvT92XvQJuuU94MI8iaCcKqukzEVweiDgNAMFbeJr9U2EuC5ZSI3MrJdjnZLqdE5JyIvEvip_MrY9Ob9iidI0j48xlXoFVnkyXawZFG0wasZon25kDbuc7s_2MBefHxRpCa_QXuv6vT</recordid><startdate>199808</startdate><enddate>199808</enddate><creator>Biagiotti, Roberto</creator><creator>Brizn, Laura</creator><creator>Periti, Enrico</creator><creator>D'Agata, Albertino</creator><creator>VanZi, Ermanno</creator><creator>Cariati, Ettore</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199808</creationdate><title>First trimester screening for Down's syndrome using maternal serum PAPP‐A and free β=hCG in combination with fetal nuchal translucency thickness</title><author>Biagiotti, Roberto ; Brizn, Laura ; Periti, Enrico ; D'Agata, Albertino ; VanZi, Ermanno ; Cariati, Ettore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4507-69493c80ac8b4f4d8d209c29a20f09368fd9554cc20fb021221db9a1f8936c1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Down Syndrome - blood</topic><topic>Down Syndrome - diagnosis</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Neck - embryology</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy-Associated Plasma Protein-A - analysis</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal Diagnosis - methods</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biagiotti, Roberto</creatorcontrib><creatorcontrib>Brizn, Laura</creatorcontrib><creatorcontrib>Periti, Enrico</creatorcontrib><creatorcontrib>D'Agata, Albertino</creatorcontrib><creatorcontrib>VanZi, Ermanno</creatorcontrib><creatorcontrib>Cariati, Ettore</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biagiotti, Roberto</au><au>Brizn, Laura</au><au>Periti, Enrico</au><au>D'Agata, Albertino</au><au>VanZi, Ermanno</au><au>Cariati, Ettore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First trimester screening for Down's syndrome using maternal serum PAPP‐A and free β=hCG in combination with fetal nuchal translucency thickness</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1998-08</date><risdate>1998</risdate><volume>105</volume><issue>8</issue><spage>917</spage><epage>920</epage><pages>917-920</pages><issn>1470-0328</issn><issn>0306-5456</issn><eissn>1471-0528</eissn><eissn>1365-215X</eissn><coden>BJOGAS</coden><abstract>The aim of this study was to evaluate the potential effectiveness of maternal serum pregnancy‐associated plasma protein A (PAPP‐A) and free β‐hCG in combination with nuchal translucency thickness in first trimester screening for Down's syndrome. 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| ispartof | BJOG : an international journal of obstetrics and gynaecology, 1998-08, Vol.105 (8), p.917-920 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Chorionic Gonadotropin - blood Down Syndrome - blood Down Syndrome - diagnosis False Positive Reactions Female Gynecology. Andrology. Obstetrics Humans Management. Prenatal diagnosis Medical sciences Neck - embryology Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A - analysis Pregnancy. Fetus. Placenta Prenatal Diagnosis - methods Sensitivity and Specificity |
| title | First trimester screening for Down's syndrome using maternal serum PAPP‐A and free β=hCG in combination with fetal nuchal translucency thickness |
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