Randomised trial of growth hormone in short normal girls
There are few data on the long-term outcome of growth-hormone treatment in short normal children. We assessed the impact of growth-hormone treatment on pubertal development and near-final height in girls. In a randomised controlled trial, we studied ten girls, with a mean age of 8·07 years and heigh...
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| Veröffentlicht in: | The Lancet (British edition) 1998-03, Vol.351 (9107), p.940-944 |
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| creator | McCaughey, Elizabeth S Mulligan, Jean Voss, Linda D Betts, Peter R |
| description | There are few data on the long-term outcome of growth-hormone treatment in short normal children. We assessed the impact of growth-hormone treatment on pubertal development and near-final height in girls.
In a randomised controlled trial, we studied ten girls, with a mean age of 8·07 years and height 2 SDs or more below the mean for their age, and eight short untreated controls matched for age, and 20 short untreated girls who did not give consent for randomisation. The girls received either 30 IU/m
2
somatropin per week as daily subcutaneous injections or no treatment. We assessed pubertal staging and height gain every 6 months.
Eight treated girls completed a mean of 6·2 years' therapy. By a mean age of 16·4 years, their mean height SD score had changed significantly from −2·42 to −1·14 (p=0·008) and they were, on average, 7·5 cm taller than the girls in the control group (height SD scores did not change significantly from −2·55) and 6·0 cm taller than the non-consent group. The timing of each pubertal stage, and the age and amplitude of peak height velocity were similar for all groups.
Growth-hormone therapy effectively increased height SD score among short normal girls started on treatment in early to mid childhood, with no untoward effect on pubertal progression. |
| doi_str_mv | 10.1016/S0140-6736(05)60604-6 |
| format | Article |
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In a randomised controlled trial, we studied ten girls, with a mean age of 8·07 years and height 2 SDs or more below the mean for their age, and eight short untreated controls matched for age, and 20 short untreated girls who did not give consent for randomisation. The girls received either 30 IU/m
2
somatropin per week as daily subcutaneous injections or no treatment. We assessed pubertal staging and height gain every 6 months.
Eight treated girls completed a mean of 6·2 years' therapy. By a mean age of 16·4 years, their mean height SD score had changed significantly from −2·42 to −1·14 (p=0·008) and they were, on average, 7·5 cm taller than the girls in the control group (height SD scores did not change significantly from −2·55) and 6·0 cm taller than the non-consent group. The timing of each pubertal stage, and the age and amplitude of peak height velocity were similar for all groups.
Growth-hormone therapy effectively increased height SD score among short normal girls started on treatment in early to mid childhood, with no untoward effect on pubertal progression.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(05)60604-6</identifier><identifier>PMID: 9734940</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Body Height - drug effects ; Child ; Female ; Hormones. Endocrine system ; Human Growth Hormone - therapeutic use ; Humans ; Medical sciences ; Pharmacology. Drug treatments ; Puberty ; Treatment Outcome</subject><ispartof>The Lancet (British edition), 1998-03, Vol.351 (9107), p.940-944</ispartof><rights>1998 Elsevier Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-256b3dacc700615563a89726f0ad4ed101e06400e90010db04648f525296fbcc3</citedby><cites>FETCH-LOGICAL-c389t-256b3dacc700615563a89726f0ad4ed101e06400e90010db04648f525296fbcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0140-6736(05)60604-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64387</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2184129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9734940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCaughey, Elizabeth S</creatorcontrib><creatorcontrib>Mulligan, Jean</creatorcontrib><creatorcontrib>Voss, Linda D</creatorcontrib><creatorcontrib>Betts, Peter R</creatorcontrib><title>Randomised trial of growth hormone in short normal girls</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>There are few data on the long-term outcome of growth-hormone treatment in short normal children. We assessed the impact of growth-hormone treatment on pubertal development and near-final height in girls.
In a randomised controlled trial, we studied ten girls, with a mean age of 8·07 years and height 2 SDs or more below the mean for their age, and eight short untreated controls matched for age, and 20 short untreated girls who did not give consent for randomisation. The girls received either 30 IU/m
2
somatropin per week as daily subcutaneous injections or no treatment. We assessed pubertal staging and height gain every 6 months.
Eight treated girls completed a mean of 6·2 years' therapy. By a mean age of 16·4 years, their mean height SD score had changed significantly from −2·42 to −1·14 (p=0·008) and they were, on average, 7·5 cm taller than the girls in the control group (height SD scores did not change significantly from −2·55) and 6·0 cm taller than the non-consent group. The timing of each pubertal stage, and the age and amplitude of peak height velocity were similar for all groups.
Growth-hormone therapy effectively increased height SD score among short normal girls started on treatment in early to mid childhood, with no untoward effect on pubertal progression.</description><subject>Biological and medical sciences</subject><subject>Body Height - drug effects</subject><subject>Child</subject><subject>Female</subject><subject>Hormones. Endocrine system</subject><subject>Human Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Puberty</subject><subject>Treatment Outcome</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc378hEEvRPSietImaXMlMvyCgeAHeBfSJN0ibTOTTvHfm21lt17lkPOckzcPQhMMVxgwu34FTCBlRc4ugF4yYEBStofGmBQkpaT42EfjHXKIjkL4BADCgI7QiBc54QTGqHyRnXatDUYnvbeySVydzL376RfJwvnWdSaxXRJi3SddvIjE3PomnKCDWjbBnA7nMXq_v3ubPqaz54en6e0sVXnJ-zSjrMq1VKoAYJhSlsuSFxmrQWpidPyJAUYADAfAoKsYkJQ1zWjGWV0plR-j8-3epXdfKxN6EcMq0zSyM24VRJFznHFKIki3oPIuBG9qsfS2lf5XYBBrY2JjTKx1CKBiY0ywODcZHlhVrdG7qUFR7J8NfRmUbGovO2XDDstwSWKAiN1sMRNlfFvjRVDWdMpo643qhXb2nyB_u-yF7A</recordid><startdate>19980328</startdate><enddate>19980328</enddate><creator>McCaughey, Elizabeth S</creator><creator>Mulligan, Jean</creator><creator>Voss, Linda D</creator><creator>Betts, Peter R</creator><general>Elsevier Ltd</general><general>Lancet</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980328</creationdate><title>Randomised trial of growth hormone in short normal girls</title><author>McCaughey, Elizabeth S ; Mulligan, Jean ; Voss, Linda D ; Betts, Peter R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-256b3dacc700615563a89726f0ad4ed101e06400e90010db04648f525296fbcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Body Height - drug effects</topic><topic>Child</topic><topic>Female</topic><topic>Hormones. Endocrine system</topic><topic>Human Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Puberty</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCaughey, Elizabeth S</creatorcontrib><creatorcontrib>Mulligan, Jean</creatorcontrib><creatorcontrib>Voss, Linda D</creatorcontrib><creatorcontrib>Betts, Peter R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCaughey, Elizabeth S</au><au>Mulligan, Jean</au><au>Voss, Linda D</au><au>Betts, Peter R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomised trial of growth hormone in short normal girls</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1998-03-28</date><risdate>1998</risdate><volume>351</volume><issue>9107</issue><spage>940</spage><epage>944</epage><pages>940-944</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>There are few data on the long-term outcome of growth-hormone treatment in short normal children. We assessed the impact of growth-hormone treatment on pubertal development and near-final height in girls.
In a randomised controlled trial, we studied ten girls, with a mean age of 8·07 years and height 2 SDs or more below the mean for their age, and eight short untreated controls matched for age, and 20 short untreated girls who did not give consent for randomisation. The girls received either 30 IU/m
2
somatropin per week as daily subcutaneous injections or no treatment. We assessed pubertal staging and height gain every 6 months.
Eight treated girls completed a mean of 6·2 years' therapy. By a mean age of 16·4 years, their mean height SD score had changed significantly from −2·42 to −1·14 (p=0·008) and they were, on average, 7·5 cm taller than the girls in the control group (height SD scores did not change significantly from −2·55) and 6·0 cm taller than the non-consent group. The timing of each pubertal stage, and the age and amplitude of peak height velocity were similar for all groups.
Growth-hormone therapy effectively increased height SD score among short normal girls started on treatment in early to mid childhood, with no untoward effect on pubertal progression.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>9734940</pmid><doi>10.1016/S0140-6736(05)60604-6</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1998-03, Vol.351 (9107), p.940-944 |
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| language | eng |
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| source | MEDLINE; Business Source Complete; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Biological and medical sciences Body Height - drug effects Child Female Hormones. Endocrine system Human Growth Hormone - therapeutic use Humans Medical sciences Pharmacology. Drug treatments Puberty Treatment Outcome |
| title | Randomised trial of growth hormone in short normal girls |
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