Effects of compound 48/80 on the guinea-pig isolated heart: A comparison with the in vitro cardiac anaphylaxis

The actions of bolus injections of 50 μg of compound 48/80 were analysed upon the isolated heart of the guinea-pig perfused according the Langendorff's method. A first injection produces positive inotropic and chronotropic effects which are rapidly replaced by negative inotropism and a decrease...

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Veröffentlicht in:	Pharmacological research communications 1981-10, Vol.13 (9), p.873-890
Hauptverfasser:	Gomes, J.C., Antonio, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylaxis - physiopathology Animals Coronary Circulation - drug effects Female Guinea Pigs Heart - drug effects Histamine - analysis In Vitro Techniques Indomethacin - pharmacology Male Myocardial Contraction - drug effects Myocardium - analysis p-Methoxy-N-methylphenethylamine - pharmacology
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