Immunologic characteristics of intestinal lymphoid cells of the guinea pig
Populations of lymphoid cells from the gastrointestinal tract of guinea pigs were compared with splenic cells for both morphologic and functional characteristics. Gastrointestinal lymphoid cells were isolated from mesenteric lymph nodes, Peyer's patches, and also from the epithelium and lamina...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1982-02, Vol.82 (2), p.248-253 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Arnaud-Battandier, Franck Nelson, David L. |
| description | Populations of lymphoid cells from the gastrointestinal tract of guinea pigs were compared with splenic cells for both morphologic and functional characteristics. Gastrointestinal lymphoid cells were isolated from mesenteric lymph nodes, Peyer's patches, and also from the epithelium and lamina propria of the small intestinal mucosa. Isolated intraepithelial and lamina propria lymphocyte populations contained (a) T cells, B cells, and macrophages; (b) T cells that proliferated to phytohemagglutinin and concanavalin A; and (c) B cells that proliferated to bacterial lipopolysaccharide. Using inbred guinea pigs, the intraephithelial and lamina propria lymphocytes were shown to contain T cells capable of proliferating to alloantigens in mixed leukocyte culture, and also cells capable of stimulating alloreactive T cells. These studies demonstrate the presence of immunologically reactive T cells and B cells in isolated small intestinal mucosal lymphoid cells from guinea pigs. |
| doi_str_mv | 10.1016/0016-5085(82)90012-9 |
| format | Article |
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Gastrointestinal lymphoid cells were isolated from mesenteric lymph nodes, Peyer's patches, and also from the epithelium and lamina propria of the small intestinal mucosa. Isolated intraepithelial and lamina propria lymphocyte populations contained (a) T cells, B cells, and macrophages; (b) T cells that proliferated to phytohemagglutinin and concanavalin A; and (c) B cells that proliferated to bacterial lipopolysaccharide. Using inbred guinea pigs, the intraephithelial and lamina propria lymphocytes were shown to contain T cells capable of proliferating to alloantigens in mixed leukocyte culture, and also cells capable of stimulating alloreactive T cells. These studies demonstrate the presence of immunologically reactive T cells and B cells in isolated small intestinal mucosal lymphoid cells from guinea pigs.</description><identifier>ISSN: 0016-5085</identifier><identifier>ISSN: 1528-0012</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(82)90012-9</identifier><identifier>PMID: 6459261</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; B-Lymphocytes - immunology ; Guinea Pigs ; Intestinal Mucosa - cytology ; Intestine, Small - cytology ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed ; Macrophages - immunology ; Male ; Mitogens - pharmacology ; Spleen - cytology ; T-Lymphocytes - immunology</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1982-02, Vol.82 (2), p.248-253</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3499-b3146ac364d989a0bf8efe7ca6dccbf1eea92b5444e28813c363118661924b3d3</citedby><cites>FETCH-LOGICAL-c3499-b3146ac364d989a0bf8efe7ca6dccbf1eea92b5444e28813c363118661924b3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0016508582900129$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6459261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arnaud-Battandier, Franck</creatorcontrib><creatorcontrib>Nelson, David L.</creatorcontrib><title>Immunologic characteristics of intestinal lymphoid cells of the guinea pig</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Populations of lymphoid cells from the gastrointestinal tract of guinea pigs were compared with splenic cells for both morphologic and functional characteristics. Gastrointestinal lymphoid cells were isolated from mesenteric lymph nodes, Peyer's patches, and also from the epithelium and lamina propria of the small intestinal mucosa. Isolated intraepithelial and lamina propria lymphocyte populations contained (a) T cells, B cells, and macrophages; (b) T cells that proliferated to phytohemagglutinin and concanavalin A; and (c) B cells that proliferated to bacterial lipopolysaccharide. Using inbred guinea pigs, the intraephithelial and lamina propria lymphocytes were shown to contain T cells capable of proliferating to alloantigens in mixed leukocyte culture, and also cells capable of stimulating alloreactive T cells. These studies demonstrate the presence of immunologically reactive T cells and B cells in isolated small intestinal mucosal lymphoid cells from guinea pigs.</description><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>Guinea Pigs</subject><subject>Intestinal Mucosa - cytology</subject><subject>Intestine, Small - cytology</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Mitogens - pharmacology</subject><subject>Spleen - cytology</subject><subject>T-Lymphocytes - immunology</subject><issn>0016-5085</issn><issn>1528-0012</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotVb_gcKsRBejeU2abAQpPioFN7oOmcydNjKPmswI_fdm2tKlbu7lcM598CF0SfAdwUTc41jSDMvsRtJbFRVN1REak4zKdFDHaHyInKKzEL4wxopJMkIjwTNFBRmjt3ld901btUtnE7sy3tgOvAudsyFpy8Q1HUTRmCqpNvV61boisVBVW7NbQbLsXQMmWbvlOTopTRXgYt8n6PP56WP2mi7eX-azx0VqGVcqzRnhwlgmeKGkMjgvJZQwtUYU1uYlATCK5hnnHKiUhMUkI0QKQRTlOSvYBF3v9q59-93H73TtwvCTaaDtg54yhaUS03-DJMuw4HQI8l3Q-jYED6Vee1cbv9EE64G1HkDqAaSWVG9ZaxXHrvb7-7yG4jC0hxv9h50PkcaPA6-DddBYKJwH2-midX8f-AVqyY13</recordid><startdate>198202</startdate><enddate>198202</enddate><creator>Arnaud-Battandier, Franck</creator><creator>Nelson, David L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198202</creationdate><title>Immunologic characteristics of intestinal lymphoid cells of the guinea pig</title><author>Arnaud-Battandier, Franck ; Nelson, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3499-b3146ac364d989a0bf8efe7ca6dccbf1eea92b5444e28813c363118661924b3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>B-Lymphocytes - immunology</topic><topic>Guinea Pigs</topic><topic>Intestinal Mucosa - cytology</topic><topic>Intestine, Small - cytology</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Macrophages - immunology</topic><topic>Male</topic><topic>Mitogens - pharmacology</topic><topic>Spleen - cytology</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arnaud-Battandier, Franck</creatorcontrib><creatorcontrib>Nelson, David L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arnaud-Battandier, Franck</au><au>Nelson, David L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunologic characteristics of intestinal lymphoid cells of the guinea pig</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1982-02</date><risdate>1982</risdate><volume>82</volume><issue>2</issue><spage>248</spage><epage>253</epage><pages>248-253</pages><issn>0016-5085</issn><issn>1528-0012</issn><eissn>1528-0012</eissn><abstract>Populations of lymphoid cells from the gastrointestinal tract of guinea pigs were compared with splenic cells for both morphologic and functional characteristics. Gastrointestinal lymphoid cells were isolated from mesenteric lymph nodes, Peyer's patches, and also from the epithelium and lamina propria of the small intestinal mucosa. Isolated intraepithelial and lamina propria lymphocyte populations contained (a) T cells, B cells, and macrophages; (b) T cells that proliferated to phytohemagglutinin and concanavalin A; and (c) B cells that proliferated to bacterial lipopolysaccharide. Using inbred guinea pigs, the intraephithelial and lamina propria lymphocytes were shown to contain T cells capable of proliferating to alloantigens in mixed leukocyte culture, and also cells capable of stimulating alloreactive T cells. These studies demonstrate the presence of immunologically reactive T cells and B cells in isolated small intestinal mucosal lymphoid cells from guinea pigs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6459261</pmid><doi>10.1016/0016-5085(82)90012-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-5085 |
| ispartof | Gastroenterology (New York, N.Y. 1943), 1982-02, Vol.82 (2), p.248-253 |
| issn | 0016-5085 1528-0012 1528-0012 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Animals B-Lymphocytes - immunology Guinea Pigs Intestinal Mucosa - cytology Intestine, Small - cytology Lymphocyte Activation Lymphocyte Culture Test, Mixed Macrophages - immunology Male Mitogens - pharmacology Spleen - cytology T-Lymphocytes - immunology |
| title | Immunologic characteristics of intestinal lymphoid cells of the guinea pig |
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