Spontaneous and Fas-mediated apoptosis are diminished in umbilical cord blood neutrophils compared with adult neutrophils

Apoptosis mediates neutrophil (PMN) phagocytosis and is influenced by cytokines and the Fas/Fas ligand pathway. To determine whether apoptosis of cord blood PMN differs from those of adults, cultured PMN were evaluated by morphological analysis, flow cytometry (TUNEL assay), and DNA gel electrophore...

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Veröffentlicht in:	Journal of leukocyte biology 1998-09, Vol.64 (3), p.331-336
Hauptverfasser:	Allgaier, Bernhard, Shi, Min, Luo, DeFang, Koenig, Joyce M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aging - blood Apoptosis - drug effects Apoptosis - physiology Cells, Cultured cycloheximide Cycloheximide - pharmacology Fas Ligand Protein fas Receptor - blood fas Receptor - physiology FasL Fetal Blood - cytology Fetal Blood - drug effects Fetal Blood - metabolism Flow Cytometry Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans Immunoglobulin M - pharmacology Membrane Glycoproteins - blood Membrane Glycoproteins - physiology Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Protein Synthesis Inhibitors - pharmacology
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