Effect of supplemental β-carotene on plasma concentrations of carotenoids, retinol, and α-tocopherol in humans
High doses of beta-carotene, a lipid-soluble nutrient, may affect the plasma concentrations of other lipid-soluble nutrients. The purpose of this study was to assess the effects of long-term daily supplementation with beta-carotene (50 mg/d) on circulating concentrations of other carotenoids, retino...
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| Veröffentlicht in: | The American journal of clinical nutrition 1998-09, Vol.68 (3), p.642-647 |
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| container_title | The American journal of clinical nutrition |
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| creator | MAYNE, S. T CARTMEL, B SILVA, F KIM, C. S FALLON, B. G BRISKIN, K TONGZHANG ZHENG BAUM, M SHOR-POSNER, G GOODWIN, W. J |
| description | High doses of beta-carotene, a lipid-soluble nutrient, may affect the plasma concentrations of other lipid-soluble nutrients. The purpose of this study was to assess the effects of long-term daily supplementation with beta-carotene (50 mg/d) on circulating concentrations of other carotenoids, retinol, and alpha-tocopherol over time. Data were available from 259 men and women participating in the Carotene Prevention Trial, a 2-center chemoprevention trial designed to determine whether supplemental beta-carotene can prevent second malignant tumors in patients cured of an early stage cancer of the oral cavity, pharynx, or larynx. Up to 2 blood samples were obtained before the intervention (before and after a 1-mo placebo run-in), with postrandomization samples obtained at 3, 12, 24, 36, 48, and 60 mo. Supplementation with beta-carotene produced a persistent 9- to 10-fold increase in median plasma beta-carotene concentrations (225 nmol/L at baseline to 2255 nmol/L at 3 mo) and a persistent 2-fold increase in median plasma alpha-carotene concentrations (45 nmol/L at baseline to 95 nmol/L at 3 mo). Concentrations of retinol, alpha-tocopherol, lycopene, and lutein/zeaxanthin were not affected by supplemental beta-carotene. Up to 5 y of daily supplementation with beta-carotene increased circulating concentrations of alpha- and beta-carotene, but did not alter concentrations of lycopene, lutein/zeaxanthin, retinol, or alpha-tocopherol. |
| doi_str_mv | 10.1093/ajcn/68.3.642 |
| format | Article |
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T ; CARTMEL, B ; SILVA, F ; KIM, C. S ; FALLON, B. G ; BRISKIN, K ; TONGZHANG ZHENG ; BAUM, M ; SHOR-POSNER, G ; GOODWIN, W. J</creator><creatorcontrib>MAYNE, S. T ; CARTMEL, B ; SILVA, F ; KIM, C. S ; FALLON, B. G ; BRISKIN, K ; TONGZHANG ZHENG ; BAUM, M ; SHOR-POSNER, G ; GOODWIN, W. J</creatorcontrib><description>High doses of beta-carotene, a lipid-soluble nutrient, may affect the plasma concentrations of other lipid-soluble nutrients. The purpose of this study was to assess the effects of long-term daily supplementation with beta-carotene (50 mg/d) on circulating concentrations of other carotenoids, retinol, and alpha-tocopherol over time. Data were available from 259 men and women participating in the Carotene Prevention Trial, a 2-center chemoprevention trial designed to determine whether supplemental beta-carotene can prevent second malignant tumors in patients cured of an early stage cancer of the oral cavity, pharynx, or larynx. Up to 2 blood samples were obtained before the intervention (before and after a 1-mo placebo run-in), with postrandomization samples obtained at 3, 12, 24, 36, 48, and 60 mo. Supplementation with beta-carotene produced a persistent 9- to 10-fold increase in median plasma beta-carotene concentrations (225 nmol/L at baseline to 2255 nmol/L at 3 mo) and a persistent 2-fold increase in median plasma alpha-carotene concentrations (45 nmol/L at baseline to 95 nmol/L at 3 mo). Concentrations of retinol, alpha-tocopherol, lycopene, and lutein/zeaxanthin were not affected by supplemental beta-carotene. Up to 5 y of daily supplementation with beta-carotene increased circulating concentrations of alpha- and beta-carotene, but did not alter concentrations of lycopene, lutein/zeaxanthin, retinol, or alpha-tocopherol.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/68.3.642</identifier><identifier>PMID: 9734742</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Clinical Nutrition</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antioxidants ; beta Carotene - administration & dosage ; beta Carotene - therapeutic use ; Biological and medical sciences ; Carotenoids - blood ; Dietary Supplements ; Dose-Response Relationship, Drug ; Double-Blind Method ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. 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Data were available from 259 men and women participating in the Carotene Prevention Trial, a 2-center chemoprevention trial designed to determine whether supplemental beta-carotene can prevent second malignant tumors in patients cured of an early stage cancer of the oral cavity, pharynx, or larynx. Up to 2 blood samples were obtained before the intervention (before and after a 1-mo placebo run-in), with postrandomization samples obtained at 3, 12, 24, 36, 48, and 60 mo. Supplementation with beta-carotene produced a persistent 9- to 10-fold increase in median plasma beta-carotene concentrations (225 nmol/L at baseline to 2255 nmol/L at 3 mo) and a persistent 2-fold increase in median plasma alpha-carotene concentrations (45 nmol/L at baseline to 95 nmol/L at 3 mo). Concentrations of retinol, alpha-tocopherol, lycopene, and lutein/zeaxanthin were not affected by supplemental beta-carotene. Up to 5 y of daily supplementation with beta-carotene increased circulating concentrations of alpha- and beta-carotene, but did not alter concentrations of lycopene, lutein/zeaxanthin, retinol, or alpha-tocopherol.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antioxidants</subject><subject>beta Carotene - administration & dosage</subject><subject>beta Carotene - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - blood</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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T</au><au>CARTMEL, B</au><au>SILVA, F</au><au>KIM, C. S</au><au>FALLON, B. G</au><au>BRISKIN, K</au><au>TONGZHANG ZHENG</au><au>BAUM, M</au><au>SHOR-POSNER, G</au><au>GOODWIN, W. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of supplemental β-carotene on plasma concentrations of carotenoids, retinol, and α-tocopherol in humans</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>68</volume><issue>3</issue><spage>642</spage><epage>647</epage><pages>642-647</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>High doses of beta-carotene, a lipid-soluble nutrient, may affect the plasma concentrations of other lipid-soluble nutrients. The purpose of this study was to assess the effects of long-term daily supplementation with beta-carotene (50 mg/d) on circulating concentrations of other carotenoids, retinol, and alpha-tocopherol over time. Data were available from 259 men and women participating in the Carotene Prevention Trial, a 2-center chemoprevention trial designed to determine whether supplemental beta-carotene can prevent second malignant tumors in patients cured of an early stage cancer of the oral cavity, pharynx, or larynx. Up to 2 blood samples were obtained before the intervention (before and after a 1-mo placebo run-in), with postrandomization samples obtained at 3, 12, 24, 36, 48, and 60 mo. Supplementation with beta-carotene produced a persistent 9- to 10-fold increase in median plasma beta-carotene concentrations (225 nmol/L at baseline to 2255 nmol/L at 3 mo) and a persistent 2-fold increase in median plasma alpha-carotene concentrations (45 nmol/L at baseline to 95 nmol/L at 3 mo). Concentrations of retinol, alpha-tocopherol, lycopene, and lutein/zeaxanthin were not affected by supplemental beta-carotene. Up to 5 y of daily supplementation with beta-carotene increased circulating concentrations of alpha- and beta-carotene, but did not alter concentrations of lycopene, lutein/zeaxanthin, retinol, or alpha-tocopherol.</abstract><cop>Bethesda, MD</cop><pub>American Society for Clinical Nutrition</pub><pmid>9734742</pmid><doi>10.1093/ajcn/68.3.642</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of clinical nutrition, 1998-09, Vol.68 (3), p.642-647 |
| issn | 0002-9165 1938-3207 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Antioxidants beta Carotene - administration & dosage beta Carotene - therapeutic use Biological and medical sciences Carotenoids - blood Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Male Middle Aged Neoplasm Recurrence, Local - prevention & control Nutrition Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin A Vitamin A - blood Vitamin E - blood |
| title | Effect of supplemental β-carotene on plasma concentrations of carotenoids, retinol, and α-tocopherol in humans |
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