Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle

The role of the L-type calcium channel in human heart failure is unclear, on the basis of previous whole-cell recordings. We investigated the properties of L-type calcium channels in left ventricular myocytes isolated from nonfailing donor hearts (n= 16 cells) or failing hearts of transplant recipie...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1998-09, Vol.98 (10), p.969-976
Hauptverfasser:	SCHRÖDER, F, HANDROCK, R, BEUCKELMANN, D. J, HIRT, S, HULLIN, R, PRIEBE, L, SCHWINGER, R. H. G, WEIL, J, HERZIG, S
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology Biological and medical sciences Calcium Channels - physiology Calcium Channels, L-Type Cardiology. Vascular system Cardiomyopathies - physiopathology Cardiomyopathy, Dilated - physiopathology Cells, Cultured Cyclic AMP - physiology Heart Heart - physiology Heart - physiopathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Ventricles Humans Ion Channel Gating Kinetics Medical sciences Membrane Potentials Myocardial Ischemia - physiopathology Probability Reference Values Time Factors
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