Agrobacterium T-DNA: a silver bullet for filamentous fungi?
Agrobacterium tumefaciens has been a steadfast servant of the plant research community over the past 25 years. Few would dispute the impact of A. tumefaciens mediated transformation on the identification and isolation of plant genes in both basic research and biotechnology. Indeed, Walden and Schell...
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| Veröffentlicht in: | Nature biotechnology 1998-09, Vol.16 (9), p.817-818 |
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| creator | Dunn-Coleman, N. (Genencor International, Palo Alto, CA.) Wang, H |
| description | Agrobacterium tumefaciens has been a steadfast servant of the plant research community over the past 25 years. Few would dispute the impact of A. tumefaciens mediated transformation on the identification and isolation of plant genes in both basic research and biotechnology. Indeed, Walden and Schell have described activation T-DNA tagging - the process by which A. tumefaciens mediated transformation is used to overexpress a target gene - as "a silver bullet approach to isolating plant genes." Now, the kingdom of A. tumefaciens has been extended to include the filamentous fungi as well. In this issue, de Groot et al. describe the transformation of several different fungi using an A. tumefaciens-mediated system. Their report details the first documented transformation of a commercial strain of Agaricus bisporus and suggests that A. tumefaciens T-DNA (which shares no homology with fungal DNA) can integrate randomly and as a single copy into fungal chromosomes. The work opens the possibility of designing a "silver bullet" T-DNA gene tagging system for fungi that may one day rival systems used in plants. |
| doi_str_mv | 10.1038/nbt0998-817 |
| format | Article |
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Their report details the first documented transformation of a commercial strain of Agaricus bisporus and suggests that A. tumefaciens T-DNA (which shares no homology with fungal DNA) can integrate randomly and as a single copy into fungal chromosomes. 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(Genencor International, Palo Alto, CA.)</creatorcontrib><creatorcontrib>Wang, H</creatorcontrib><title>Agrobacterium T-DNA: a silver bullet for filamentous fungi?</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>Agrobacterium tumefaciens has been a steadfast servant of the plant research community over the past 25 years. Few would dispute the impact of A. tumefaciens mediated transformation on the identification and isolation of plant genes in both basic research and biotechnology. Indeed, Walden and Schell have described activation T-DNA tagging - the process by which A. tumefaciens mediated transformation is used to overexpress a target gene - as "a silver bullet approach to isolating plant genes." Now, the kingdom of A. tumefaciens has been extended to include the filamentous fungi as well. 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| identifier | ISSN: 1087-0156 |
| ispartof | Nature biotechnology, 1998-09, Vol.16 (9), p.817-818 |
| issn | 1087-0156 1546-1696 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; Alma/SFX Local Collection |
| subjects | Agriculture AGROBACTERIUM TUMEFACIENS Agrobacterium tumefaciens - genetics analysis Bioinformatics Biolistics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology DNA Transposable Elements DNA, Bacterial - administration & dosage DNA, Bacterial - genetics DNA, Single-Stranded - administration & dosage DNA, Single-Stranded - genetics GENE TRANSFER GENETIC TRANSFORMATION Life Sciences Neurospora crassa - genetics TRANSFERENCIA DE GENES TRANSFERT DE GENE TRANSFORMACION GENETICA TRANSFORMATION GENETIQUE Transformation, Genetic |
| title | Agrobacterium T-DNA: a silver bullet for filamentous fungi? |
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