Potential role for imidazole in the rhythmic respiratory activity of the in vitro neonatal rat brainstem

We used the imidazole-binding agent, diethylpyrocarbonate (DEPC), to test the hypothesis that rhythmic respiratory activity of the in vitro neonatal rat brainstem-spinal cord preparation was functionally dependent on imidazole. Neural activity was recorded from spinal nerves (C1-C4) during superfusi...

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Veröffentlicht in:	Neuroscience letters 1998-07, Vol.251 (3), p.153-156
Hauptverfasser:	Krause, William L, Kazemi, Homayoun, Burton, Melvin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphastat hypothesis Animals Animals, Newborn Biological and medical sciences Brain Stem - drug effects Brain Stem - physiology Control of breathing Diethyl Pyrocarbonate - metabolism Diethyl Pyrocarbonate - pharmacology Diethylpyrocarbonate Fundamental and applied biological sciences. Psychology Histidine - physiology Hydroxylamine - pharmacology Imidazole-histidine Imidazoles - antagonists & inhibitors Imidazoles - metabolism In Vitro Techniques Medulla Oblongata - drug effects Microinjections Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Periodicity Rats Rats, Sprague-Dawley Respiration - drug effects Spinal Cord - drug effects Spinal Cord - physiology Vertebrates: nervous system and sense organs
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