Methyl hypofluorite in the synthesis of 16-methoxyestradiol stereoisomers

The unusual chemistry of methyl hypofluorite provides a previously unexplored route for functionalizing the 16-position of estradiol. Three isomers of 16-methoxyestradiol were prepared via two synthetic routes, each using methyl hypofluorite. The estrogen receptor binding affinity of these compounds...

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Veröffentlicht in:	Steroids 1998-09, Vol.63 (9), p.470-478
Hauptverfasser:	Jonson, Stephanie D, d’Avignon, D.André, Katzenellenbogen, John A, Welch, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	16-methoxyestradiol Alicyclic compounds, terpenoids, prostaglandins, steroids Biological and medical sciences Chemistry Contrast media. Radiopharmaceuticals Esters - chemistry Estradiol - analogs & derivatives Estradiol - chemical synthesis Estradiol - chemistry Estradiol - metabolism Exact sciences and technology HMQC-TOCSY Hydrocarbons, Fluorinated Indicators and Reagents Magnetic Resonance Spectroscopy Medical sciences methyl hypofluorite Molecular Structure NOESY Organic chemistry Pharmacology. Drug treatments Preparations and properties Protein Binding Receptors, Estrogen - metabolism Stereoisomerism Steroids Tomography, Emission-Computed
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