Apolipoprotein(a) Enhances Platelet Responses to the Thrombin Receptor-Activating Peptide SFLLRN

Elevated levels of lipoprotein(a) [Lp(a)] are correlated with an increased risk of atherosclerotic disease. We examined the effect of recombinant apolipoprotein(a) [r-apo(a)] and Lp(a) on responses of washed human platelets, prelabeled in the dense granules with [() C]serotonin and suspended in Tyro...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1998-09, Vol.18 (9), p.1393-1399
Hauptverfasser:	Rand, Margaret L, Sangrar, Waheed, Hancock, Mark A, Taylor, Desiree M, Marcovina, Santica M, Packham, Marian A, Koschinsky, Marlys L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Apolipoproteins A - pharmacology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Platelets - drug effects Cardiology. Vascular system Cell Line Embryo, Mammalian Humans Kidney Medical sciences Peptide Fragments - pharmacology Platelet Activation - drug effects Platelet Aggregation - drug effects Receptors, Thrombin - drug effects Receptors, Thrombin - physiology Recombinant Proteins - pharmacology
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