Strands of embryonic mesencephalic tissue show greater dopamine neuron survival and better behavioral improvement than cell suspensions after transplantation in parkinsonian rats

The success of embryonic neural transplants as a treatment for patients with Parkinson's disease has been limited by poor survival of transplanted dopamine neurons. To see if a new partially intact tissue preparation method improves survival, we have developed a technique for extruding embryoni...

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Veröffentlicht in:	Brain research 1998-09, Vol.806 (1), p.60-68
Hauptverfasser:	Clarkson, Edward D., Zawada, W.Michael, Adams, Frank S., Bell, K.Pat, Freed, Curt R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Behavior, Animal - drug effects Behavior, Animal - physiology bFGF Biological and medical sciences Cell Size - physiology Cell Survival - physiology Cell Transplantation Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Fetal Tissue Transplantation - methods GDNF Graft Survival - physiology Growth factors IGF-I Male Matrigel Medical sciences Mesencephalon - cytology Mesencephalon - embryology Mesencephalon - metabolism Methamphetamine Methamphetamine - pharmacology Neurology Neurons - cytology Neurons - physiology Parkinson Disease - psychology Parkinson Disease - surgery Rats Rats, Sprague-Dawley Stereotyped Behavior - physiology
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