Effect of Human C-Reactive Protein on Chemokine and Chemotactic Factor-Induced Neutrophil Chemotaxis and Signaling

C-reactive protein (CRP) is a unique serum pentraxin and the prototype acute phase reactant. CRP is a ligand for specific receptors on phagocytic leukocytes, and mediates activation reactions of monocytes/macrophages, but inhibits the respiratory burst of neutrophils (PMN). Since CRP selectively acc...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-09, Vol.161 (5), p.2533-2540
Hauptverfasser:	Zhong, Wangjian, Zen, Qin, Tebo, Julie, Schlottmann, Klaus, Coggeshall, Mark, Mortensen, Richard F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - pharmacology Antigens, CD - drug effects Antigens, CD - metabolism C-Reactive Protein - metabolism C-Reactive Protein - pharmacology Calcium-Calmodulin-Dependent Protein Kinases - drug effects Calcium-Calmodulin-Dependent Protein Kinases - metabolism Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - immunology HL-60 Cells Humans Interleukin-8 - metabolism Interleukin-8 - pharmacology Molecular Sequence Data N-Formylmethionine Leucyl-Phenylalanine - analogs & derivatives N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - drug effects Neutrophils - enzymology Neutrophils - immunology Peptide Fragments - pharmacology Phosphatidylinositol 3-Kinases - drug effects Phosphatidylinositol 3-Kinases - metabolism Protein Binding - drug effects Receptors, Immunologic - immunology Receptors, Interleukin - drug effects Receptors, Interleukin - metabolism Receptors, Interleukin-8A Signal Transduction - drug effects Signal Transduction - immunology
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