The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats
The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizure...
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| Veröffentlicht in: | Brain research bulletin 1998-07, Vol.46 (5), p.461-465 |
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| creator | KAKINOKI, H ISHIZAWA, K FUKUNAGA, M FUJII, Y KAMEI, C |
| description | The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment. |
| doi_str_mv | 10.1016/s0361-9230(98)00048-3 |
| format | Article |
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Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. 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Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.</description><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - drug effects</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Histamine Antagonists - pharmacology</subject><subject>Histamine N-Methyltransferase - antagonists & inhibitors</subject><subject>Imidazoles - administration & dosage</subject><subject>Imidazoles - pharmacology</subject><subject>Injections, Intraventricular</subject><subject>Kindling, Neurologic - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - pharmacology</subject><subject>Pyrimethamine - analogs & derivatives</subject><subject>Pyrimethamine - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Histamine H3 - metabolism</subject><subject>Seizures - physiopathology</subject><subject>Thiourea - administration & dosage</subject><subject>Thiourea - analogs & derivatives</subject><subject>Thiourea - pharmacology</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1PAyEURYnRaK3-BBMWxuhiFObNMMzSNH4lJi6scUkoPBSdjwrTRf31Ujvp6i3uufA4EHLG2TVnXNxEBoJndQ7sspZXjLFCZrBHJlxWkOVVUe2TyQ45IscxfiVIyFIcksO6gppxNiHv80-k6ByaIdLe0U8fB936DukjZAENLoc-UN0N-qPvUpagjup2_WF103tLv31nG7Q0ov9dBYzUdzToIZ6QA6ebiKfjnJK3-7v57DF7fnl4mt0-ZwZ4MaTdKqtNDaxCYcFZVupc1qI0egE5SgQnXQ6l4KihMhws5iWXpRVVjUlCDlNysT13GfqfFcZBtT4abBrdYb-KavtOWSaw3IIm9DEGdGoZfKvDWnGmNkLV68aW2thStVT_QhWk3tl4wWrRot21RoMpPx9zHY1uXNCd8XGH5QUT6TPgDyDsfcI</recordid><startdate>19980715</startdate><enddate>19980715</enddate><creator>KAKINOKI, H</creator><creator>ISHIZAWA, K</creator><creator>FUKUNAGA, M</creator><creator>FUJII, Y</creator><creator>KAMEI, C</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980715</creationdate><title>The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats</title><author>KAKINOKI, H ; ISHIZAWA, K ; FUKUNAGA, M ; FUJII, Y ; KAMEI, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-927dac9307e6d3fd05a28965cab32e8e3f8f23561ea37c13de25185d679e01623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amygdala - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - drug effects</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Histamine Antagonists - pharmacology</topic><topic>Histamine N-Methyltransferase - antagonists & inhibitors</topic><topic>Imidazoles - administration & dosage</topic><topic>Imidazoles - pharmacology</topic><topic>Injections, Intraventricular</topic><topic>Kindling, Neurologic - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Piperidines - administration & dosage</topic><topic>Piperidines - pharmacology</topic><topic>Pyrimethamine - analogs & derivatives</topic><topic>Pyrimethamine - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Histamine H3 - metabolism</topic><topic>Seizures - physiopathology</topic><topic>Thiourea - administration & dosage</topic><topic>Thiourea - analogs & derivatives</topic><topic>Thiourea - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAKINOKI, H</creatorcontrib><creatorcontrib>ISHIZAWA, K</creatorcontrib><creatorcontrib>FUKUNAGA, M</creatorcontrib><creatorcontrib>FUJII, Y</creatorcontrib><creatorcontrib>KAMEI, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAKINOKI, H</au><au>ISHIZAWA, K</au><au>FUKUNAGA, M</au><au>FUJII, Y</au><au>KAMEI, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1998-07-15</date><risdate>1998</risdate><volume>46</volume><issue>5</issue><spage>461</spage><epage>465</epage><pages>461-465</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>9739010</pmid><doi>10.1016/s0361-9230(98)00048-3</doi><tpages>5</tpages></addata></record> |
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| subjects | Amygdala - physiology Animals Biological and medical sciences Brain Chemistry - drug effects Enzyme Inhibitors - pharmacology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Histamine Antagonists - pharmacology Histamine N-Methyltransferase - antagonists & inhibitors Imidazoles - administration & dosage Imidazoles - pharmacology Injections, Intraventricular Kindling, Neurologic - physiology Male Medical sciences Nervous system (semeiology, syndromes) Neurology Piperidines - administration & dosage Piperidines - pharmacology Pyrimethamine - analogs & derivatives Pyrimethamine - pharmacology Rats Rats, Wistar Receptors, Histamine H3 - metabolism Seizures - physiopathology Thiourea - administration & dosage Thiourea - analogs & derivatives Thiourea - pharmacology |
| title | The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats |
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