Characterization of the Recombinant MutY Homolog, an Adenine DNA Glycosylase, from Yeast Schizosaccharomyces pombe

The mutY homolog (SpMYH) gene from a cDNA library of Schizosaccharomyces pombeencodes a protein of 461 amino acids that displays 28 and 31% identity to Escherichia coli MutY and human MutY homolog (MYH), respectively. Expressed SpMYH is able to complement an E. coli mutY mutant to reduce the mutatio...

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Veröffentlicht in:	The Journal of biological chemistry 1998-09, Vol.273 (39), p.25098-25105
Hauptverfasser:	Lu, A-Lien, Fawcett, William P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence AMINO ACID SEQUENCES APURINIC/APYRIMIDINIC LYASE Base Sequence CHEMICAL COMPOSITION COMPLEMENTARY DNA COMPLEMENTATION DNA DNA Glycosylases DNA Primers Edetic Acid ENZYMIC ACTIVITY ESCHERICHIA COLI Escherichia coli - genetics GENBANK/AF053340 GENES GENETICS HYDROLASES Kinetics MOLECULAR SEQUENCE DATA MUTANTS Mutation N-GLYCOSIDE HYDROLASES N-Glycosyl Hydrolases - chemistry N-Glycosyl Hydrolases - metabolism Nucleic Acid Heteroduplexes NUCLEOTIDE SEQUENCE Protein Binding Recombinant Proteins - chemistry Recombinant Proteins - metabolism Salts Schizosaccharomyces - enzymology SCHIZOSACCHAROMYCES POMBE Sequence Homology, Amino Acid SPMYH GENE STRUCTURAL GENES Substrate Specificity
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