The Selection and Design of Topical and Transdermal Agents: A Review
One of the major problems in topical and transdermal drug delivery is the efficiency of the barrier property of the stratum corneum. Topical and transdermal agents were often originally designed as drugs to be given orally. In this paper a mechanistic evaluation of skin penetration shows that topica...
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| Veröffentlicht in: | The Journal of investigative dermatology symposium proceedings 1998-08, Vol.3 (2), p.131-135 |
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| container_title | The Journal of investigative dermatology symposium proceedings |
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| creator | Hadgraft, Jonathan John Pugh, W. |
| description | One of the major problems in topical and transdermal drug delivery is the efficiency of the barrier property of the stratum corneum. Topical and transdermal agents were often originally designed as drugs to be given orally. In this paper a mechanistic evaluation of skin penetration shows that topical and transdermal drugs should be designed using different strategies. The relative effects of basic physicochemical parameters are examined. An understanding, at a molecular level, of the permeation process will enable us to produce more effective topical agents and to extend the repertoire of transdermal drugs. Journal of Investigative Dermatology Symposium Proceedings 3:131–135, 1998 |
| doi_str_mv | 10.1038/jidsymp.1998.27 |
| format | Article |
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| ispartof | The Journal of investigative dermatology symposium proceedings, 1998-08, Vol.3 (2), p.131-135 |
| issn | 1087-0024 1529-1774 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Administration, Cutaneous Administration, Topical Animals Designer Drugs - administration & dosage Designer Drugs - chemistry Designer Drugs - pharmacokinetics drug design enhancers Humans Models, Molecular skin Skin - metabolism topical drugs transdermal |
| title | The Selection and Design of Topical and Transdermal Agents: A Review |
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