CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

INK4 and CIP/KIP are two distinct families of cyclin-dependent kinase (CDK) inhibitors implicated in mediating a wide range of cell growth control signals. We have created p18(INK4c)-deficient mice. These mice develop gigantism and widespread organomegaly. The pituitary gland, spleen, and thymus are...

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Veröffentlicht in:	Genes & development 1998-09, Vol.12 (18), p.2899-2911
Hauptverfasser:	Franklin, D S, Godfrey, V L, Lee, H, Kovalev, G I, Schoonhoven, R, Chen-Kiang, S, Su, L, Xiong, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - etiology Adenoma - genetics Adenoma - prevention & control Animals B-Lymphocytes - immunology B-Lymphocytes - pathology Body Constitution - genetics Carrier Proteins - genetics Carrier Proteins - physiology Cell Cycle - genetics Cell Cycle - physiology Cell Cycle Proteins Cell Division - genetics Cell Division - physiology Cyclin-Dependent Kinase Inhibitor p18 Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - antagonists & inhibitors Enzyme Inhibitors - metabolism Female Gene Targeting Lymphocyte Activation - genetics Lymphocyte Activation - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - physiology Pituitary Neoplasms - etiology Pituitary Neoplasms - genetics Pituitary Neoplasms - prevention & control Splenomegaly - etiology Splenomegaly - genetics T-Lymphocytes - immunology T-Lymphocytes - pathology Tumor Suppressor Proteins
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