Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens
Although many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance immune function. Tylosin is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin...
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| Veröffentlicht in: | Poultry science 1998-09, Vol.77 (9), p.1306-1311 |
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| creator | Baba, T. (Osaka Prefecture University, Sakai, Osaka, Japan.) Yamashita, N Kodama, H Murkamoto, M Asada, M Nakamoto, K Nose, Y McGruders, E.D |
| description | Although many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance immune function. Tylosin is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on cellular immune functions in chickens. There was no significant difference in adherent splenocyte chemotaxis between tylosin-treated and untreated (control) chickens. Tylosin increased splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels. Removal of adherent splenocytes before preparation of CM caused a reduction in CM proliferative activity. Tylosin also increased anti- tumor activity of splenocytes. These data are the first to suggest that the macrolide antibiotic, tylosin tartrate, has a modulatory effect in chickens on the immune parameters studied |
| doi_str_mv | 10.1093/ps/77.9.1306 |
| format | Article |
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(Osaka Prefecture University, Sakai, Osaka, Japan.) ; Yamashita, N ; Kodama, H ; Murkamoto, M ; Asada, M ; Nakamoto, K ; Nose, Y ; McGruders, E.D</creator><creatorcontrib>Baba, T. (Osaka Prefecture University, Sakai, Osaka, Japan.) ; Yamashita, N ; Kodama, H ; Murkamoto, M ; Asada, M ; Nakamoto, K ; Nose, Y ; McGruders, E.D</creatorcontrib><description>Although many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance immune function. Tylosin is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on cellular immune functions in chickens. There was no significant difference in adherent splenocyte chemotaxis between tylosin-treated and untreated (control) chickens. Tylosin increased splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels. Removal of adherent splenocytes before preparation of CM caused a reduction in CM proliferative activity. Tylosin also increased anti- tumor activity of splenocytes. These data are the first to suggest that the macrolide antibiotic, tylosin tartrate, has a modulatory effect in chickens on the immune parameters studied</description><identifier>ISSN: 0032-5791</identifier><identifier>EISSN: 1525-3171</identifier><identifier>DOI: 10.1093/ps/77.9.1306</identifier><identifier>PMID: 9733118</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Bronchi - cytology ; Cell Adhesion ; CELL CULTURE ; Cell Division - drug effects ; CELL MEDIATED IMMUNITY ; CELLS ; CELLULE ; CELULAS ; Chemotaxis, Leukocyte ; CHICKENS ; Chickens - immunology ; CITOQUINAS ; CULTIVO DE CELULAS ; CULTURE DE CELLULE ; CULTURE MEDIA ; Culture Media, Conditioned ; CYTOKINE ; CYTOKINES ; IMMUNITE CELLULAIRE ; Immunity, Cellular - drug effects ; IMMUNOSTIMULATION NON SPECIFIQUE ; INMUNIDAD CELULAR ; INMUNOESTIMULACION NO ESPECIFICA ; Killer Cells, Natural - immunology ; LINFOCITOS ; LYMPHOCYTE ; Lymphocyte Activation - drug effects ; LYMPHOCYTE TRANSFORMATION ; LYMPHOCYTES ; Lymphocytes - immunology ; MEDIO DE CULTIVO ; MILIEU DE CULTURE ; Mitogens - pharmacology ; NATURAL KILLER CELLS ; NONSPECIFIC IMMUNOSTIMULATION ; POLLO ; POULET ; Pulmonary Alveoli - cytology ; Spleen - cytology ; Spleen - immunology ; SPLEEN CELLS ; TILOSINA ; TYLOSIN ; Tylosin - pharmacology ; TYLOSINE</subject><ispartof>Poultry science, 1998-09, Vol.77 (9), p.1306-1311</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-9c7fe3d41845e016d2c76c36128909ad52d11a11d5cdeacccb73b41f29af69013</citedby><cites>FETCH-LOGICAL-c346t-9c7fe3d41845e016d2c76c36128909ad52d11a11d5cdeacccb73b41f29af69013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9733118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baba, T. (Osaka Prefecture University, Sakai, Osaka, Japan.)</creatorcontrib><creatorcontrib>Yamashita, N</creatorcontrib><creatorcontrib>Kodama, H</creatorcontrib><creatorcontrib>Murkamoto, M</creatorcontrib><creatorcontrib>Asada, M</creatorcontrib><creatorcontrib>Nakamoto, K</creatorcontrib><creatorcontrib>Nose, Y</creatorcontrib><creatorcontrib>McGruders, E.D</creatorcontrib><title>Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens</title><title>Poultry science</title><addtitle>Poult Sci</addtitle><description>Although many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance immune function. Tylosin is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on cellular immune functions in chickens. There was no significant difference in adherent splenocyte chemotaxis between tylosin-treated and untreated (control) chickens. Tylosin increased splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels. Removal of adherent splenocytes before preparation of CM caused a reduction in CM proliferative activity. Tylosin also increased anti- tumor activity of splenocytes. These data are the first to suggest that the macrolide antibiotic, tylosin tartrate, has a modulatory effect in chickens on the immune parameters studied</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bronchi - cytology</subject><subject>Cell Adhesion</subject><subject>CELL CULTURE</subject><subject>Cell Division - drug effects</subject><subject>CELL MEDIATED IMMUNITY</subject><subject>CELLS</subject><subject>CELLULE</subject><subject>CELULAS</subject><subject>Chemotaxis, Leukocyte</subject><subject>CHICKENS</subject><subject>Chickens - immunology</subject><subject>CITOQUINAS</subject><subject>CULTIVO DE CELULAS</subject><subject>CULTURE DE CELLULE</subject><subject>CULTURE MEDIA</subject><subject>Culture Media, Conditioned</subject><subject>CYTOKINE</subject><subject>CYTOKINES</subject><subject>IMMUNITE CELLULAIRE</subject><subject>Immunity, Cellular - drug effects</subject><subject>IMMUNOSTIMULATION NON SPECIFIQUE</subject><subject>INMUNIDAD CELULAR</subject><subject>INMUNOESTIMULACION NO ESPECIFICA</subject><subject>Killer Cells, Natural - immunology</subject><subject>LINFOCITOS</subject><subject>LYMPHOCYTE</subject><subject>Lymphocyte Activation - drug effects</subject><subject>LYMPHOCYTE TRANSFORMATION</subject><subject>LYMPHOCYTES</subject><subject>Lymphocytes - immunology</subject><subject>MEDIO DE CULTIVO</subject><subject>MILIEU DE CULTURE</subject><subject>Mitogens - pharmacology</subject><subject>NATURAL KILLER CELLS</subject><subject>NONSPECIFIC IMMUNOSTIMULATION</subject><subject>POLLO</subject><subject>POULET</subject><subject>Pulmonary Alveoli - cytology</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>SPLEEN CELLS</subject><subject>TILOSINA</subject><subject>TYLOSIN</subject><subject>Tylosin - pharmacology</subject><subject>TYLOSINE</subject><issn>0032-5791</issn><issn>1525-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAURS0EKqWwsSJ5QiCR1i9O7HhEVfmQKjG0nS3HsSHgxMFOhv57UlHBdId33tXVQegayByIoIsuLjifizlQwk7QFPI0TyhwOEVTQmia5FzAObqI8ZOQFBjjEzQRnFKAYoo2K2uN7rG3uN87H-sW9yr0QfUG3233TrV4491QOnOPfYu1cW5wKuC6aYbW4GBi59toIh4f9Uetv0wbL9GZVS6aq2PO0O5ptV2-JOu359fl4zrRNGN9IjS3hlYZFFluCLAq1ZxpyiAtBBGqytMKQAFUua6M0lqXnJYZ2FQoywQBOkO3v71d8N-Dib1s6nhYqFrjhyg5LQQlIhvBh19QBx9jMFZ2oW5U2Esg8uBQdiPNpZAHhyN-c-wdysZUf_BR2v_dKi_Ve6ij3G1ACEEICMboDwvVdbg</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Baba, T. (Osaka Prefecture University, Sakai, Osaka, Japan.)</creator><creator>Yamashita, N</creator><creator>Kodama, H</creator><creator>Murkamoto, M</creator><creator>Asada, M</creator><creator>Nakamoto, K</creator><creator>Nose, Y</creator><creator>McGruders, E.D</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens</title><author>Baba, T. (Osaka Prefecture University, Sakai, Osaka, Japan.) ; Yamashita, N ; Kodama, H ; Murkamoto, M ; Asada, M ; Nakamoto, K ; Nose, Y ; McGruders, E.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-9c7fe3d41845e016d2c76c36128909ad52d11a11d5cdeacccb73b41f29af69013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bronchi - cytology</topic><topic>Cell Adhesion</topic><topic>CELL CULTURE</topic><topic>Cell Division - drug effects</topic><topic>CELL MEDIATED IMMUNITY</topic><topic>CELLS</topic><topic>CELLULE</topic><topic>CELULAS</topic><topic>Chemotaxis, Leukocyte</topic><topic>CHICKENS</topic><topic>Chickens - immunology</topic><topic>CITOQUINAS</topic><topic>CULTIVO DE CELULAS</topic><topic>CULTURE DE CELLULE</topic><topic>CULTURE MEDIA</topic><topic>Culture Media, Conditioned</topic><topic>CYTOKINE</topic><topic>CYTOKINES</topic><topic>IMMUNITE CELLULAIRE</topic><topic>Immunity, Cellular - drug effects</topic><topic>IMMUNOSTIMULATION NON SPECIFIQUE</topic><topic>INMUNIDAD CELULAR</topic><topic>INMUNOESTIMULACION NO ESPECIFICA</topic><topic>Killer Cells, Natural - immunology</topic><topic>LINFOCITOS</topic><topic>LYMPHOCYTE</topic><topic>Lymphocyte Activation - drug effects</topic><topic>LYMPHOCYTE TRANSFORMATION</topic><topic>LYMPHOCYTES</topic><topic>Lymphocytes - immunology</topic><topic>MEDIO DE CULTIVO</topic><topic>MILIEU DE CULTURE</topic><topic>Mitogens - pharmacology</topic><topic>NATURAL KILLER CELLS</topic><topic>NONSPECIFIC IMMUNOSTIMULATION</topic><topic>POLLO</topic><topic>POULET</topic><topic>Pulmonary Alveoli - cytology</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>SPLEEN CELLS</topic><topic>TILOSINA</topic><topic>TYLOSIN</topic><topic>Tylosin - pharmacology</topic><topic>TYLOSINE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baba, T. (Osaka Prefecture University, Sakai, Osaka, Japan.)</creatorcontrib><creatorcontrib>Yamashita, N</creatorcontrib><creatorcontrib>Kodama, H</creatorcontrib><creatorcontrib>Murkamoto, M</creatorcontrib><creatorcontrib>Asada, M</creatorcontrib><creatorcontrib>Nakamoto, K</creatorcontrib><creatorcontrib>Nose, Y</creatorcontrib><creatorcontrib>McGruders, E.D</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Poultry science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baba, T. 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There was no significant difference in adherent splenocyte chemotaxis between tylosin-treated and untreated (control) chickens. Tylosin increased splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels. Removal of adherent splenocytes before preparation of CM caused a reduction in CM proliferative activity. Tylosin also increased anti- tumor activity of splenocytes. These data are the first to suggest that the macrolide antibiotic, tylosin tartrate, has a modulatory effect in chickens on the immune parameters studied</abstract><cop>England</cop><pmid>9733118</pmid><doi>10.1093/ps/77.9.1306</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-5791 |
| ispartof | Poultry science, 1998-09, Vol.77 (9), p.1306-1311 |
| issn | 0032-5791 1525-3171 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73893094 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Anti-Bacterial Agents - pharmacology Bronchi - cytology Cell Adhesion CELL CULTURE Cell Division - drug effects CELL MEDIATED IMMUNITY CELLS CELLULE CELULAS Chemotaxis, Leukocyte CHICKENS Chickens - immunology CITOQUINAS CULTIVO DE CELULAS CULTURE DE CELLULE CULTURE MEDIA Culture Media, Conditioned CYTOKINE CYTOKINES IMMUNITE CELLULAIRE Immunity, Cellular - drug effects IMMUNOSTIMULATION NON SPECIFIQUE INMUNIDAD CELULAR INMUNOESTIMULACION NO ESPECIFICA Killer Cells, Natural - immunology LINFOCITOS LYMPHOCYTE Lymphocyte Activation - drug effects LYMPHOCYTE TRANSFORMATION LYMPHOCYTES Lymphocytes - immunology MEDIO DE CULTIVO MILIEU DE CULTURE Mitogens - pharmacology NATURAL KILLER CELLS NONSPECIFIC IMMUNOSTIMULATION POLLO POULET Pulmonary Alveoli - cytology Spleen - cytology Spleen - immunology SPLEEN CELLS TILOSINA TYLOSIN Tylosin - pharmacology TYLOSINE |
| title | Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens |
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