Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296
Pharmacokinetics of [14C]-ITF-296 and its metabolites, ITF-1124 and ITF-1577, were studied in dogs and monkeys after a single intravenous (2.5 mg/kg) and oral (10 mg/kg) administration. Radioactivity was measured by LSC while unchanged drug and its metabolites in plasma were assayed by an HPLC-UV me...
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| Veröffentlicht in: | European journal of drug metabolism and pharmacokinetics 1998-04, Vol.23 (2), p.239-250 |
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| container_title | European journal of drug metabolism and pharmacokinetics |
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| creator | GIACHETTI, C BERTOLINO, M CANALI, S LOMBARDINI, E MONZANI, M. V SALA, A ZANOLO, G |
| description | Pharmacokinetics of [14C]-ITF-296 and its metabolites, ITF-1124 and ITF-1577, were studied in dogs and monkeys after a single intravenous (2.5 mg/kg) and oral (10 mg/kg) administration. Radioactivity was measured by LSC while unchanged drug and its metabolites in plasma were assayed by an HPLC-UV method. The absorption of [14C]-ITF-296 after oral administration is practically complete both in dogs and in monkeys. The determination of unchanged drug and its metabolites shows quite a similar profile in dogs and monkeys for ITF-296 and ITF-1124 and a different time-course for ITF-1577. Elimination of radioactivity occurs mainly in urine (namely 70-80%) for both species and the recovery of the dose (higher than 90%) takes place up to 96 h after both treatments. |
| doi_str_mv | 10.1007/BF03189346 |
| format | Article |
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V</creatorcontrib><creatorcontrib>SALA, A</creatorcontrib><creatorcontrib>ZANOLO, G</creatorcontrib><title>Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296</title><title>European journal of drug metabolism and pharmacokinetics</title><addtitle>Eur J Drug Metab Pharmacokinet</addtitle><description>Pharmacokinetics of [14C]-ITF-296 and its metabolites, ITF-1124 and ITF-1577, were studied in dogs and monkeys after a single intravenous (2.5 mg/kg) and oral (10 mg/kg) administration. Radioactivity was measured by LSC while unchanged drug and its metabolites in plasma were assayed by an HPLC-UV method. The absorption of [14C]-ITF-296 after oral administration is practically complete both in dogs and in monkeys. The determination of unchanged drug and its metabolites shows quite a similar profile in dogs and monkeys for ITF-296 and ITF-1124 and a different time-course for ITF-1577. Elimination of radioactivity occurs mainly in urine (namely 70-80%) for both species and the recovery of the dose (higher than 90%) takes place up to 96 h after both treatments.</description><subject>Absorption</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Benzoxazines</subject><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes</subject><subject>Cardiovascular system</subject><subject>Dogs</subject><subject>Injections, Intravenous</subject><subject>Ischemia - prevention & control</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitrates - blood</subject><subject>Nitrates - pharmacokinetics</subject><subject>Oxazines - blood</subject><subject>Oxazines - pharmacokinetics</subject><subject>Pharmacology. 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| identifier | ISSN: 0378-7966 |
| ispartof | European journal of drug metabolism and pharmacokinetics, 1998-04, Vol.23 (2), p.239-250 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Absorption Administration, Oral Animals Antianginal agents. Coronary vasodilator agents Benzoxazines Biological and medical sciences Carbon Radioisotopes Cardiovascular system Dogs Injections, Intravenous Ischemia - prevention & control Macaca fascicularis Male Medical sciences Nitrates - blood Nitrates - pharmacokinetics Oxazines - blood Oxazines - pharmacokinetics Pharmacology. Drug treatments |
| title | Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296 |
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