Zonal Induction of Mixed Lineage Kinase ZPK/DLK/MUK Gene Expression in Regenerating Mouse Liver
ZPK/DLK/MUK is a serine/threonine kinase believed to be involved in the regulation of cell growth and differentiation. To further explore the suggested participation of ZPK/DLK/MUK in this process, we examined the expression and cellular localization of ZPK/DLK/MUK mRNA in regenerating mouse liver f...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1998-08, Vol.249 (3), p.927-932 |
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| creator | Douziech, Mélanie Grondin, Gilles Loranger, Anne Marceau, Normand Blouin, Richard |
| description | ZPK/DLK/MUK is a serine/threonine kinase believed to be involved in the regulation of cell growth and differentiation. To further explore the suggested participation of ZPK/DLK/MUK in this process, we examined the expression and cellular localization of ZPK/DLK/MUK mRNA in regenerating mouse liver following partial hepatectomy by ribonuclease protection assay andin situhybridization. The steady-state level of ZPK/DLK/MUK mRNA was very low in normal and sham-operated mouse livers, whereas a marked and transient increase was observed in the regenerating liver. While ZPK/DLK/MUK mRNAs were rarely detected in hepatocytes from all zones of the normal liver, hepatocytes of regenerating liver exhibit a gradient of expression ranging from low in the periportal zone, to intermediate in the mid-zone, to high in the pericentral zone. These findings demonstrate a transient stimulation of ZPK/DLK/MUK gene expression that correlates with the growth response of hepatocyte subpopulations in regenerating liver. |
| doi_str_mv | 10.1006/bbrc.1998.9249 |
| format | Article |
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These findings demonstrate a transient stimulation of ZPK/DLK/MUK gene expression that correlates with the growth response of hepatocyte subpopulations in regenerating liver.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1998.9249</identifier><identifier>PMID: 9731238</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Gene Expression ; Hepatectomy ; In Situ Hybridization ; Liver Regeneration - genetics ; Liver Regeneration - physiology ; MAP Kinase Kinase Kinases ; Mice ; Protein Kinases - genetics ; Protein-Serine-Threonine Kinases - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signal Transduction ; Tissue Distribution</subject><ispartof>Biochemical and biophysical research communications, 1998-08, Vol.249 (3), p.927-932</ispartof><rights>1998 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-1d362d14ca55e6c75153916f9127702ebc2e841c926639c6213af1284c3eb69b3</citedby><cites>FETCH-LOGICAL-c370t-1d362d14ca55e6c75153916f9127702ebc2e841c926639c6213af1284c3eb69b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.1998.9249$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9731238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Douziech, Mélanie</creatorcontrib><creatorcontrib>Grondin, Gilles</creatorcontrib><creatorcontrib>Loranger, Anne</creatorcontrib><creatorcontrib>Marceau, Normand</creatorcontrib><creatorcontrib>Blouin, Richard</creatorcontrib><title>Zonal Induction of Mixed Lineage Kinase ZPK/DLK/MUK Gene Expression in Regenerating Mouse Liver</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>ZPK/DLK/MUK is a serine/threonine kinase believed to be involved in the regulation of cell growth and differentiation. 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These findings demonstrate a transient stimulation of ZPK/DLK/MUK gene expression that correlates with the growth response of hepatocyte subpopulations in regenerating liver.</description><subject>Animals</subject><subject>Gene Expression</subject><subject>Hepatectomy</subject><subject>In Situ Hybridization</subject><subject>Liver Regeneration - genetics</subject><subject>Liver Regeneration - physiology</subject><subject>MAP Kinase Kinase Kinases</subject><subject>Mice</subject><subject>Protein Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction</subject><subject>Tissue Distribution</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun5cvQk5eetuJmnT5ih-s10UURAvIU2nS2Q3XZOu6L-3ZRdv4mlg5nlfhoeQU2BjYExOqirYMShVjBVP1Q4ZAVMs4cDSXTJiPZFwBa8H5DDGd8YAUqn2yb7KBXBRjIh-a71Z0Htfr23nWk_bhs7cF9a0dB7NHOnUeRORvj1OJ1fldDJ7mdJb9Eivv1YBYxwyztMnnPfLYDrn53TWrvtE6T4xHJO9xiwinmznEXm5uX6-vEvKh9v7y4sysSJnXQK1kLyG1JosQ2nzDDKhQDYKeJ4zjpXlWKRgFZdSKCs5CNMAL1IrsJKqEkfkfNO7Cu3HGmOnly5aXCyMx_4bnYtCARTsXxByyAqR8x4cb0Ab2hgDNnoV3NKEbw1MD-r1oF4P6vWgvg-cbZvX1RLrX3zrur8Xmzv2Hj4dBh2tQ2-xdgFtp-vW_VX9AxEDkG4</recordid><startdate>19980828</startdate><enddate>19980828</enddate><creator>Douziech, Mélanie</creator><creator>Grondin, Gilles</creator><creator>Loranger, Anne</creator><creator>Marceau, Normand</creator><creator>Blouin, Richard</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19980828</creationdate><title>Zonal Induction of Mixed Lineage Kinase ZPK/DLK/MUK Gene Expression in Regenerating Mouse Liver</title><author>Douziech, Mélanie ; Grondin, Gilles ; Loranger, Anne ; Marceau, Normand ; Blouin, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-1d362d14ca55e6c75153916f9127702ebc2e841c926639c6213af1284c3eb69b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Gene Expression</topic><topic>Hepatectomy</topic><topic>In Situ Hybridization</topic><topic>Liver Regeneration - genetics</topic><topic>Liver Regeneration - physiology</topic><topic>MAP Kinase Kinase Kinases</topic><topic>Mice</topic><topic>Protein Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal Transduction</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Douziech, Mélanie</creatorcontrib><creatorcontrib>Grondin, Gilles</creatorcontrib><creatorcontrib>Loranger, Anne</creatorcontrib><creatorcontrib>Marceau, Normand</creatorcontrib><creatorcontrib>Blouin, Richard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Douziech, Mélanie</au><au>Grondin, Gilles</au><au>Loranger, Anne</au><au>Marceau, Normand</au><au>Blouin, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zonal Induction of Mixed Lineage Kinase ZPK/DLK/MUK Gene Expression in Regenerating Mouse Liver</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1998-08-28</date><risdate>1998</risdate><volume>249</volume><issue>3</issue><spage>927</spage><epage>932</epage><pages>927-932</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>ZPK/DLK/MUK is a serine/threonine kinase believed to be involved in the regulation of cell growth and differentiation. 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| ispartof | Biochemical and biophysical research communications, 1998-08, Vol.249 (3), p.927-932 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Gene Expression Hepatectomy In Situ Hybridization Liver Regeneration - genetics Liver Regeneration - physiology MAP Kinase Kinase Kinases Mice Protein Kinases - genetics Protein-Serine-Threonine Kinases - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Tissue Distribution |
| title | Zonal Induction of Mixed Lineage Kinase ZPK/DLK/MUK Gene Expression in Regenerating Mouse Liver |
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