Electrophysiologic and inotropic effects of K+-channel blockade in aged diaphragm

The aminopyridines block several types of potassium (K+) channels and exert a direct inotropic effect on skeletal muscle by prolonging the duration of the action potential. Aging influences skeletal muscle Cl- channels and their regulation, and affects both resting whole-cell K+ conductance and aden...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 1998-09, Vol.158 (3), p.820-826
Hauptverfasser:	VAN LUNTEREN, E, MOYER, M
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - analogs & derivatives 4-Aminopyridine - pharmacology Action Potentials - drug effects Adenosine Triphosphate - physiology Aging - physiology Analysis of Variance Animals Biological and medical sciences Chloride Channels - antagonists & inhibitors Diaphragm - drug effects Diaphragm - physiology Investigative techniques of respiratory function Investigative techniques, diagnostic techniques (general aspects) Isometric Contraction - drug effects Male Medical sciences Membrane Potentials - drug effects Muscle Contraction - drug effects Muscle, Skeletal - drug effects Potassium Channel Blockers Rats Rats, Inbred F344 Reaction Time - drug effects
Online-Zugang:	Volltext
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