Osteogenesis Imperfecta — Managing Brittle Bones

Osteogenesis Imperfecta — Managing Brittle Bones

Osteogenesis imperfecta is an autosomal dominant disorder of the connective tissue, which is also known as “brittle-bone disease” because it renders those affected susceptible to fractures after minimal trauma. Clinically and biochemically, osteogenesis imperfecta is a generalized disorder of the co...

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Veröffentlicht in:The New England journal of medicine 1998-10, Vol.339 (14), p.986-987
1. Verfasser: Marini, Joan C
Format: Artikel
Sprache:eng
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Child
Diphosphonates - therapeutic use
Humans
Osteogenesis Imperfecta - classification
Osteogenesis Imperfecta - drug therapy
Osteogenesis Imperfecta - therapy
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creator Marini, Joan C
description Osteogenesis imperfecta is an autosomal dominant disorder of the connective tissue, which is also known as “brittle-bone disease” because it renders those affected susceptible to fractures after minimal trauma. Clinically and biochemically, osteogenesis imperfecta is a generalized disorder of the connective tissue, characterized by various combinations of blue sclerae, triangular facies, macrocephaly, hearing loss, defective dentition, barrel chest, vertebral compression and scoliosis, progressive limb deformity and bowing, joint laxity, and varying degrees of growth retardation. The currently accepted classification of the disease includes four types defined according to clinical and radiographic features, with some overlap among them. 1 Type I is . . .
doi_str_mv 10.1056/NEJM199810013391408
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subjects Child
Diphosphonates - therapeutic use
Humans
Osteogenesis Imperfecta - classification
Osteogenesis Imperfecta - drug therapy
Osteogenesis Imperfecta - therapy
title Osteogenesis Imperfecta — Managing Brittle Bones
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