Resident cardiac mast cells degranulate and release preformed TNF-α, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion

Neutrophil-induced cardiomyocyte injury requires the expression of myocyte intercellular adhesion molecule (ICAM)-1 and ICAM-1-CD11b/CD18 adhesion. We have previously demonstrated interleukin (IL)-6 activity in postischemic cardiac lymph; IL-6 is the primary stimulus for myocyte ICAM- 1 induction. F...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1998-08, Vol.98 (7), p.699-710
Hauptverfasser:	FRANGOGIANNIS, N. G, LINDSEY, M. L, MICHAEL, L. H, YOUKER, K. A, BRESSLER, R. B, MENDOZA, L. H, SPENGLER, R. N, SMITH, C. W, ENTMAN, M. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Coronary heart disease Cytokines - biosynthesis Cytoplasmic Granules - pathology Cytoplasmic Granules - ultrastructure Dogs Endothelium, Vascular - immunology Endothelium, Vascular - physiopathology Heart Histamine Release Interleukin-1 - biosynthesis Interleukin-6 - biosynthesis Lymph Mast Cells - pathology Mast Cells - ultrastructure Medical sciences Models, Cardiovascular Myocardial Ischemia - immunology Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Myocardial Reperfusion Myocardium - immunology Myocardium - metabolism Myocardium - pathology RNA, Messenger - biosynthesis Time Factors Transcription, Genetic Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - metabolism
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