Differential recognition of MBP epitopes in BALB/c mice determines the site of inflammatory disease induction

Although myelin basic protein (MBP)-recognizing T cells are not readily obtained after immunization of BALB/c mice with MBP (reflecting the BALB/c resistance to actively induced experimental autoimmune encephalomyelitis (EAE)), they can be expanded and cloned after several rounds of in vitro culture...

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Veröffentlicht in:	Journal of neuroimmunology 1998-08, Vol.89 (1), p.73-82
Hauptverfasser:	Yoshizawa, Izumi, Bronson, Roderick, Ben-Nun, Avi, Richert, John R., Dorf, Martin E., Abromson-Leeman, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - immunology Amino Acid Substitution Animals Antibody Specificity Clone Cells Cloning, Molecular Demyelinating Diseases - immunology Epitope fine specificity Epitopes - immunology Exons - genetics Exons - immunology Female MBP isoforms Mice Mice, Inbred BALB C Mice, Neurologic Mutants Molecular Sequence Data Myelin Basic Protein - genetics Myelin Basic Protein - immunology Neuritis Neuritis - immunology Peptide Fragments - genetics Peptide Fragments - immunology Peripheral nervous system Peripheral Nervous System - immunology Receptors, Antigen, T-Cell - analysis Receptors, Antigen, T-Cell - immunology T-cell receptor sequences T-Lymphocytes - chemistry T-Lymphocytes - immunology
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