LABORATORY AND CLINICAL STUDIES ON CEFSULODIN
Laboratory and clinical studies on cefsulodin (CFS), a new antipseudomonal cephalosporin antibiotic, were carried out and the following results were obtained. 1. The MIC of CFS against P. aeruginosa showed the peak of susceptibility at 3.13mcg/ml in the inoculum size of 108cells/ml and at 1.56mcg/ml...
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| Veröffentlicht in: | Japanese journal of antibiotics 1981/10/25, Vol.34(10), pp.1416-1421 |
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| container_title | Japanese journal of antibiotics |
| container_volume | 34 |
| creator | KUMASAKA, YOSHIHIRO NAKAHATA, HISASHI ENDO, KATSUMI SASAKI, KAZUO MATSUHASHI, AKIO NARITA, SHOKO IMAMURA, KEN-ICHI TAKEBE, KAZUO MASAKI, NAOYOSHI TAMURA, TOYOKAZU |
| description | Laboratory and clinical studies on cefsulodin (CFS), a new antipseudomonal cephalosporin antibiotic, were carried out and the following results were obtained. 1. The MIC of CFS against P. aeruginosa showed the peak of susceptibility at 3.13mcg/ml in the inoculum size of 108cells/ml and at 1.56mcg/ml in the inoculum size of 106cells/ml. It has a higher superiority as compared with gentamicin or piperacillin and gentamicin-resistant strains of P. aeruginosa were sensitive to CFS. 2. CFS was given to 3 patients with acute pneumonia and 5 patients with chronic cystitis which were all due to P. aeruginosa. Clinical effects were good in 2 patients and poor in a patient with acute pneumonia, and those were good in 3 patients and poor in 2 patients with chronic cystitis. Side effects were not recognized at all. |
| doi_str_mv | 10.11553/antibiotics1968b.34.1416 |
| format | Article |
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The MIC of CFS against P. aeruginosa showed the peak of susceptibility at 3.13mcg/ml in the inoculum size of 108cells/ml and at 1.56mcg/ml in the inoculum size of 106cells/ml. It has a higher superiority as compared with gentamicin or piperacillin and gentamicin-resistant strains of P. aeruginosa were sensitive to CFS. 2. CFS was given to 3 patients with acute pneumonia and 5 patients with chronic cystitis which were all due to P. aeruginosa. Clinical effects were good in 2 patients and poor in a patient with acute pneumonia, and those were good in 3 patients and poor in 2 patients with chronic cystitis. Side effects were not recognized at all.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.34.1416</identifier><identifier>PMID: 6460884</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Adult ; Aged ; Cefsulodin ; Cephalosporins - pharmacology ; Cephalosporins - therapeutic use ; Cystitis - drug therapy ; Drug Evaluation ; Female ; Gentamicins - pharmacology ; Humans ; Male ; Middle Aged ; Penicillin Resistance ; Penicillins - pharmacology ; Piperacillin ; Pneumonia - drug therapy ; Pseudomonas aeruginosa - drug effects ; Pseudomonas Infections - drug therapy</subject><ispartof>The Japanese Journal of Antibiotics, 1981/10/25, Vol.34(10), pp.1416-1421</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6460884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUMASAKA, YOSHIHIRO</creatorcontrib><creatorcontrib>NAKAHATA, HISASHI</creatorcontrib><creatorcontrib>ENDO, KATSUMI</creatorcontrib><creatorcontrib>SASAKI, KAZUO</creatorcontrib><creatorcontrib>MATSUHASHI, AKIO</creatorcontrib><creatorcontrib>NARITA, SHOKO</creatorcontrib><creatorcontrib>IMAMURA, KEN-ICHI</creatorcontrib><creatorcontrib>TAKEBE, KAZUO</creatorcontrib><creatorcontrib>MASAKI, NAOYOSHI</creatorcontrib><creatorcontrib>TAMURA, TOYOKAZU</creatorcontrib><title>LABORATORY AND CLINICAL STUDIES ON CEFSULODIN</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>Laboratory and clinical studies on cefsulodin (CFS), a new antipseudomonal cephalosporin antibiotic, were carried out and the following results were obtained. 1. The MIC of CFS against P. aeruginosa showed the peak of susceptibility at 3.13mcg/ml in the inoculum size of 108cells/ml and at 1.56mcg/ml in the inoculum size of 106cells/ml. It has a higher superiority as compared with gentamicin or piperacillin and gentamicin-resistant strains of P. aeruginosa were sensitive to CFS. 2. CFS was given to 3 patients with acute pneumonia and 5 patients with chronic cystitis which were all due to P. aeruginosa. Clinical effects were good in 2 patients and poor in a patient with acute pneumonia, and those were good in 3 patients and poor in 2 patients with chronic cystitis. Side effects were not recognized at all.</description><subject>Adult</subject><subject>Aged</subject><subject>Cefsulodin</subject><subject>Cephalosporins - pharmacology</subject><subject>Cephalosporins - therapeutic use</subject><subject>Cystitis - drug therapy</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Gentamicins - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Penicillin Resistance</subject><subject>Penicillins - pharmacology</subject><subject>Piperacillin</subject><subject>Pneumonia - drug therapy</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas Infections - drug therapy</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkLtOw0AQRVcIFKKQT0AyDZ3DjNfeR2mcBCxZtpRHQbXatTfgyHngdQr-HgNRCpqZ4p650hxCHhAmiFFEn_S-q0196OrSoWTCTGg4wRDZFRkGKJgfhZxfkyFQJvyAC7wlY-dqAxS5CPqKARmwkIEQ4ZD4WfxcLOJVsXjz4nzqJVmap0mcecvVeprOll6Re8lsvlxnxTTN78jNRjfOjs97RNbz2Sp59bPi5efK36KEzjdaVrLcIIPSAudQAYZgaGBlyaw1ETVYScGqaKPBSmo1GgqmByXyksqIjsjjX--xPXyerOvUrnalbRq9t4eTU5wKAUJCD96fwZPZ2Uod23qn2y91_q_Ps7986zr9bi-5bnt7jVX_VSoaKoTf2Qu9YOWHbpXd029aXGzd</recordid><startdate>198110</startdate><enddate>198110</enddate><creator>KUMASAKA, YOSHIHIRO</creator><creator>NAKAHATA, HISASHI</creator><creator>ENDO, KATSUMI</creator><creator>SASAKI, KAZUO</creator><creator>MATSUHASHI, AKIO</creator><creator>NARITA, SHOKO</creator><creator>IMAMURA, KEN-ICHI</creator><creator>TAKEBE, KAZUO</creator><creator>MASAKI, NAOYOSHI</creator><creator>TAMURA, TOYOKAZU</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198110</creationdate><title>LABORATORY AND CLINICAL STUDIES ON CEFSULODIN</title><author>KUMASAKA, YOSHIHIRO ; NAKAHATA, HISASHI ; ENDO, KATSUMI ; SASAKI, KAZUO ; MATSUHASHI, AKIO ; NARITA, SHOKO ; IMAMURA, KEN-ICHI ; TAKEBE, KAZUO ; MASAKI, NAOYOSHI ; TAMURA, TOYOKAZU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j190t-ba9d9cf160ce0770d0140b32e9c6eeb53b1d986d5fa0e93ea1b30b770917c3953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cefsulodin</topic><topic>Cephalosporins - pharmacology</topic><topic>Cephalosporins - therapeutic use</topic><topic>Cystitis - drug therapy</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Gentamicins - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Penicillin Resistance</topic><topic>Penicillins - pharmacology</topic><topic>Piperacillin</topic><topic>Pneumonia - drug therapy</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Pseudomonas Infections - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KUMASAKA, YOSHIHIRO</creatorcontrib><creatorcontrib>NAKAHATA, HISASHI</creatorcontrib><creatorcontrib>ENDO, KATSUMI</creatorcontrib><creatorcontrib>SASAKI, KAZUO</creatorcontrib><creatorcontrib>MATSUHASHI, AKIO</creatorcontrib><creatorcontrib>NARITA, SHOKO</creatorcontrib><creatorcontrib>IMAMURA, KEN-ICHI</creatorcontrib><creatorcontrib>TAKEBE, KAZUO</creatorcontrib><creatorcontrib>MASAKI, NAOYOSHI</creatorcontrib><creatorcontrib>TAMURA, TOYOKAZU</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUMASAKA, YOSHIHIRO</au><au>NAKAHATA, HISASHI</au><au>ENDO, KATSUMI</au><au>SASAKI, KAZUO</au><au>MATSUHASHI, AKIO</au><au>NARITA, SHOKO</au><au>IMAMURA, KEN-ICHI</au><au>TAKEBE, KAZUO</au><au>MASAKI, NAOYOSHI</au><au>TAMURA, TOYOKAZU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LABORATORY AND CLINICAL STUDIES ON CEFSULODIN</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1981-10</date><risdate>1981</risdate><volume>34</volume><issue>10</issue><spage>1416</spage><epage>1421</epage><pages>1416-1421</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>Laboratory and clinical studies on cefsulodin (CFS), a new antipseudomonal cephalosporin antibiotic, were carried out and the following results were obtained. 1. The MIC of CFS against P. aeruginosa showed the peak of susceptibility at 3.13mcg/ml in the inoculum size of 108cells/ml and at 1.56mcg/ml in the inoculum size of 106cells/ml. It has a higher superiority as compared with gentamicin or piperacillin and gentamicin-resistant strains of P. aeruginosa were sensitive to CFS. 2. CFS was given to 3 patients with acute pneumonia and 5 patients with chronic cystitis which were all due to P. aeruginosa. Clinical effects were good in 2 patients and poor in a patient with acute pneumonia, and those were good in 3 patients and poor in 2 patients with chronic cystitis. Side effects were not recognized at all.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>6460884</pmid><doi>10.11553/antibiotics1968b.34.1416</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1981/10/25, Vol.34(10), pp.1416-1421 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Cefsulodin Cephalosporins - pharmacology Cephalosporins - therapeutic use Cystitis - drug therapy Drug Evaluation Female Gentamicins - pharmacology Humans Male Middle Aged Penicillin Resistance Penicillins - pharmacology Piperacillin Pneumonia - drug therapy Pseudomonas aeruginosa - drug effects Pseudomonas Infections - drug therapy |
| title | LABORATORY AND CLINICAL STUDIES ON CEFSULODIN |
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