Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp functioning as repressor of heat shock transcription factor (HSF) could make activation of hsp genes dependent on protein unfolding. In a nove...

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Veröffentlicht in:	Cell 1998-08, Vol.94 (4), p.471-480
Hauptverfasser:	Zou, Jiangying, Guo, Yongle, Guettouche, Toumy, Smith, David F, Voellmy, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoquinones Cell-Free System DNA-Binding Proteins - metabolism Heat Shock Transcription Factors HSP90 Heat-Shock Proteins - metabolism Humans Lactams, Macrocyclic Models, Genetic Protein Binding - drug effects Protein Conformation Protein Denaturation Quinones - pharmacology Repressor Proteins - metabolism Rifabutin - pharmacology Transcription Factors - metabolism
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