Disappearance of AML1-MTG8 transcript by reverse transcriptase polymerase chain reaction in a patient in remission of acute myeloid leukemia (M2) after low-dose cytosine arabinoside

It is well-known that low dose cytosine arabinoside (LDAC) has activity in elderly patients with acute myeloid leukemia (AML). Several studies have shown that AML patients with t(8;21) in long term complete remission (CR) following intensive chemotherapy or allogeneic bone marrow transplantation (BM...

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Veröffentlicht in:	Leukemia research 1998-09, Vol.22 (9), p.853-857
Hauptverfasser:	Sawada, Hitoshi, Serino, Yoko, Wake, Atsushi, Yamasaki, Yoshihiro, Izumi, Yoichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Aged AML1-MTG8 Antineoplastic agents Biological and medical sciences Chemotherapy Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 8 Core Binding Factor Alpha 2 Subunit Cytarabine - therapeutic use Humans Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Low-dose cytosine arabinoside Medical sciences Minimal residual disease Neoplasm, Residual Oncogene Proteins, Fusion Pharmacology. Drug treatments Polymerase Chain Reaction Recombinant Fusion Proteins - analysis Recombinant Fusion Proteins - genetics Remission Induction Reverse transcription-polymerase chain reaction RNA, Messenger - analysis RNA-Directed DNA Polymerase RUNX1 Translocation Partner 1 Protein Transcription Factors - analysis Transcription Factors - genetics Translocation, Genetic
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