Novel antiallergic and antiinflammatory agents. Part I: Synthesis and pharmacology of glycolic amide derivatives

A series of mono-glycoloylamino derivatives was synthesized by treatment of the corresponding aromatic monoamine derivatives with glycoloyl chloride derivatives in pyridine or dichloromethane, in the presence of a base such as triethylamine or pyridine. Hydrolysis of acetoxy compounds in aqueous amm...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1998-07, Vol.6 (7), p.1069-1076
Hauptverfasser:	Ban, M, Taguchi, H, Katsushima, T, Takahashi, M, Shinoda, K, Watanabe, A, Tominaga, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amides - administration & dosage Amides - chemical synthesis Amides - chemistry Amides - pharmacology Animals Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - chemical synthesis Anti-Allergic Agents - chemistry Anti-Allergic Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Cell Adhesion - drug effects Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Eosinophils - physiology Glycolates - administration & dosage Glycolates - chemical synthesis Glycolates - chemistry Glycolates - pharmacology Humans In Vitro Techniques Ketotifen - administration & dosage Ketotifen - chemical synthesis Ketotifen - chemistry Ketotifen - pharmacology Passive Cutaneous Anaphylaxis - drug effects Rats Rats, Wistar Structure-Activity Relationship Tumor Necrosis Factor-alpha - pharmacology Umbilical Veins - cytology Umbilical Veins - drug effects Umbilical Veins - physiology
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