Reactivity to recombinant house‐dust‐mite allergens in asthma and rhinitis in a tropical environment
Background House‐dust mites contain components that are allergenic in mite‐sensitive patients, and a number of these have been produced in recombinant form. Methods In the present study, we evaluated by skin prick testing the positivity to native Der p 2 and recombinant Der p 2, Der p 5, and Der p 7...
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| Veröffentlicht in: | Allergy (Copenhagen) 1998-08, Vol.53 (8), p.808-811 |
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| creator | Lynch, N. R. Puccio, F. A. Prisco, M. C. Lopez, R. I. Hazell, L. A. Smith, W. A. Thomas, W. R. |
| description | Background House‐dust mites contain components that are allergenic in mite‐sensitive patients, and a number of these have been produced in recombinant form.
Methods In the present study, we evaluated by skin prick testing the positivity to native Der p 2 and recombinant Der p 2, Der p 5, and Der p 7 allergens of Dermatophagoides pteronyssinus in patients with rhinitis, asthma, or a combination of these diseases, who were positive to whole‐mite extract. Results In all patients, the positivity to both native and recombinant Der 2 was high. In patients with either rhinitis or asthma, the reactivity to Der p 5 and 7 was significantly lower than to Der p 2. However, in patients with combined disease, the positivity to the minor allergens was almost as high as that to Der p 2.
Conclusions These results raise the question of whether patients with combined allergic rhinitis and asthma, when compared to those with either of these diseases alone, are predisposed to react to a wider range of mite allergens, or, inversely, whether patients who respond to the minor allergens are more susceptible to suffering the combined disease. |
| doi_str_mv | 10.1111/j.1398-9995.1998.tb03979.x |
| format | Article |
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Methods In the present study, we evaluated by skin prick testing the positivity to native Der p 2 and recombinant Der p 2, Der p 5, and Der p 7 allergens of Dermatophagoides pteronyssinus in patients with rhinitis, asthma, or a combination of these diseases, who were positive to whole‐mite extract. Results In all patients, the positivity to both native and recombinant Der 2 was high. In patients with either rhinitis or asthma, the reactivity to Der p 5 and 7 was significantly lower than to Der p 2. However, in patients with combined disease, the positivity to the minor allergens was almost as high as that to Der p 2.
Conclusions These results raise the question of whether patients with combined allergic rhinitis and asthma, when compared to those with either of these diseases alone, are predisposed to react to a wider range of mite allergens, or, inversely, whether patients who respond to the minor allergens are more susceptible to suffering the combined disease.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/j.1398-9995.1998.tb03979.x</identifier><identifier>PMID: 9722232</identifier><identifier>CODEN: LLRGDY</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Inhalation ; Adolescent ; Adult ; Allergens - immunology ; Allergic diseases ; Animals ; Antigens, Dermatophagoides ; asthma ; Asthma - immunology ; Biological and medical sciences ; Child ; Dermatophagoides ; Dust - adverse effects ; Escherichia coli - genetics ; Female ; Glutathione Transferase - genetics ; Glycoproteins - immunology ; house‐dust mite ; Humans ; Immunopathology ; Male ; Medical sciences ; Middle Aged ; Mites - immunology ; recombinant allergens ; Recombinant Fusion Proteins - immunology ; Respiratory and ent allergic diseases ; rhinitis ; Rhinitis, Allergic, Perennial - immunology ; Skin Tests ; Tropical Climate ; Venezuela</subject><ispartof>Allergy (Copenhagen), 1998-08, Vol.53 (8), p.808-811</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4958-1b74c7d3a5c62a79414b38870372999c291683e77b83857ff379fa90b9de169e3</citedby><cites>FETCH-LOGICAL-c4958-1b74c7d3a5c62a79414b38870372999c291683e77b83857ff379fa90b9de169e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1398-9995.1998.tb03979.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1398-9995.1998.tb03979.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2350324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9722232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, N. R.</creatorcontrib><creatorcontrib>Puccio, F. A.</creatorcontrib><creatorcontrib>Prisco, M. C.</creatorcontrib><creatorcontrib>Lopez, R. I.</creatorcontrib><creatorcontrib>Hazell, L. A.</creatorcontrib><creatorcontrib>Smith, W. A.</creatorcontrib><creatorcontrib>Thomas, W. R.</creatorcontrib><title>Reactivity to recombinant house‐dust‐mite allergens in asthma and rhinitis in a tropical environment</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background House‐dust mites contain components that are allergenic in mite‐sensitive patients, and a number of these have been produced in recombinant form.
Methods In the present study, we evaluated by skin prick testing the positivity to native Der p 2 and recombinant Der p 2, Der p 5, and Der p 7 allergens of Dermatophagoides pteronyssinus in patients with rhinitis, asthma, or a combination of these diseases, who were positive to whole‐mite extract. Results In all patients, the positivity to both native and recombinant Der 2 was high. In patients with either rhinitis or asthma, the reactivity to Der p 5 and 7 was significantly lower than to Der p 2. However, in patients with combined disease, the positivity to the minor allergens was almost as high as that to Der p 2.
Conclusions These results raise the question of whether patients with combined allergic rhinitis and asthma, when compared to those with either of these diseases alone, are predisposed to react to a wider range of mite allergens, or, inversely, whether patients who respond to the minor allergens are more susceptible to suffering the combined disease.</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Allergens - immunology</subject><subject>Allergic diseases</subject><subject>Animals</subject><subject>Antigens, Dermatophagoides</subject><subject>asthma</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dermatophagoides</subject><subject>Dust - adverse effects</subject><subject>Escherichia coli - genetics</subject><subject>Female</subject><subject>Glutathione Transferase - genetics</subject><subject>Glycoproteins - immunology</subject><subject>house‐dust mite</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mites - immunology</subject><subject>recombinant allergens</subject><subject>Recombinant Fusion Proteins - immunology</subject><subject>Respiratory and ent allergic diseases</subject><subject>rhinitis</subject><subject>Rhinitis, Allergic, Perennial - immunology</subject><subject>Skin Tests</subject><subject>Tropical Climate</subject><subject>Venezuela</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd-K1DAUxoMo67j6CEIQ8a7d_GmbHC-EZfEfDAii1yFNT50MbTommXXnbh9hn9EnscOUuZXNzYF8v5Nz8n2EvOGs5PO52pZcgi4AoC45gC5zyyQoKO-ekNVZekpWjLO6qGqpn5MXKW0ZY0oAuyAXoIQQUqzI5jtal_2tzweaJxrRTWPrgw2ZbqZ9wr_3D90-5bmMPiO1w4DxF4ZEfaA25c1oqQ0djRsffPana5rjtPPODhTDrY9TGDHkl-RZb4eEr5Z6SX5--vjj5kux_vb56831unAV1Lrgraqc6qStXSOsgopXrdRaMTlvDuAE8EZLVKrVUteq76WC3gJroUPeAMpL8u707i5Ov_eYshl9cjgMNuD8IaOkVg1r-H9BrnjDa6Vm8P0JdHFKKWJvdtGPNh4MZ-aYh9mao-nmaLo55mGWPMzd3Px6mbJvR-zOrUsAs_520W2aHeujDc6nMyZkzaSoZuzDCfvjBzw8YgFzvV5rpuU_826qVQ</recordid><startdate>199808</startdate><enddate>199808</enddate><creator>Lynch, N. R.</creator><creator>Puccio, F. A.</creator><creator>Prisco, M. C.</creator><creator>Lopez, R. I.</creator><creator>Hazell, L. A.</creator><creator>Smith, W. A.</creator><creator>Thomas, W. R.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199808</creationdate><title>Reactivity to recombinant house‐dust‐mite allergens in asthma and rhinitis in a tropical environment</title><author>Lynch, N. R. ; Puccio, F. A. ; Prisco, M. C. ; Lopez, R. I. ; Hazell, L. A. ; Smith, W. A. ; Thomas, W. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4958-1b74c7d3a5c62a79414b38870372999c291683e77b83857ff379fa90b9de169e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Inhalation</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Allergens - immunology</topic><topic>Allergic diseases</topic><topic>Animals</topic><topic>Antigens, Dermatophagoides</topic><topic>asthma</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dermatophagoides</topic><topic>Dust - adverse effects</topic><topic>Escherichia coli - genetics</topic><topic>Female</topic><topic>Glutathione Transferase - genetics</topic><topic>Glycoproteins - immunology</topic><topic>house‐dust mite</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mites - immunology</topic><topic>recombinant allergens</topic><topic>Recombinant Fusion Proteins - immunology</topic><topic>Respiratory and ent allergic diseases</topic><topic>rhinitis</topic><topic>Rhinitis, Allergic, Perennial - immunology</topic><topic>Skin Tests</topic><topic>Tropical Climate</topic><topic>Venezuela</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, N. R.</creatorcontrib><creatorcontrib>Puccio, F. A.</creatorcontrib><creatorcontrib>Prisco, M. C.</creatorcontrib><creatorcontrib>Lopez, R. I.</creatorcontrib><creatorcontrib>Hazell, L. A.</creatorcontrib><creatorcontrib>Smith, W. A.</creatorcontrib><creatorcontrib>Thomas, W. R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, N. R.</au><au>Puccio, F. A.</au><au>Prisco, M. C.</au><au>Lopez, R. I.</au><au>Hazell, L. A.</au><au>Smith, W. A.</au><au>Thomas, W. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactivity to recombinant house‐dust‐mite allergens in asthma and rhinitis in a tropical environment</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>1998-08</date><risdate>1998</risdate><volume>53</volume><issue>8</issue><spage>808</spage><epage>811</epage><pages>808-811</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><coden>LLRGDY</coden><abstract>Background House‐dust mites contain components that are allergenic in mite‐sensitive patients, and a number of these have been produced in recombinant form.
Methods In the present study, we evaluated by skin prick testing the positivity to native Der p 2 and recombinant Der p 2, Der p 5, and Der p 7 allergens of Dermatophagoides pteronyssinus in patients with rhinitis, asthma, or a combination of these diseases, who were positive to whole‐mite extract. Results In all patients, the positivity to both native and recombinant Der 2 was high. In patients with either rhinitis or asthma, the reactivity to Der p 5 and 7 was significantly lower than to Der p 2. However, in patients with combined disease, the positivity to the minor allergens was almost as high as that to Der p 2.
Conclusions These results raise the question of whether patients with combined allergic rhinitis and asthma, when compared to those with either of these diseases alone, are predisposed to react to a wider range of mite allergens, or, inversely, whether patients who respond to the minor allergens are more susceptible to suffering the combined disease.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9722232</pmid><doi>10.1111/j.1398-9995.1998.tb03979.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Administration, Inhalation Adolescent Adult Allergens - immunology Allergic diseases Animals Antigens, Dermatophagoides asthma Asthma - immunology Biological and medical sciences Child Dermatophagoides Dust - adverse effects Escherichia coli - genetics Female Glutathione Transferase - genetics Glycoproteins - immunology house‐dust mite Humans Immunopathology Male Medical sciences Middle Aged Mites - immunology recombinant allergens Recombinant Fusion Proteins - immunology Respiratory and ent allergic diseases rhinitis Rhinitis, Allergic, Perennial - immunology Skin Tests Tropical Climate Venezuela |
| title | Reactivity to recombinant house‐dust‐mite allergens in asthma and rhinitis in a tropical environment |
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