Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair

The XPC-HR23B complex is specifically involved in global genome but not transcription-coupled nucleotide excision repair (NER). Its function is unknown. Using a novel DNA damage recognition-competition assay, we identified XPC-HR23B as the earliest damage detector to initiate NER: it acts before the...

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Veröffentlicht in:	Molecular cell 1998-08, Vol.2 (2), p.223-232
Hauptverfasser:	Sugasawa, Kaoru, Ng, Jessica M.Y, Masutani, Chikahide, Iwai, Shigenori, van der Spek, Peter J, Eker, André P.M, Hanaoka, Fumio, Bootsma, Dirk, Hoeijmakers, Jan H.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding, Competitive DNA - genetics DNA - metabolism DNA Damage DNA Repair DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genome, Human Humans In Vitro Techniques Macromolecular Substances Models, Biological Xeroderma Pigmentosum - genetics Xeroderma Pigmentosum - metabolism Xeroderma Pigmentosum Group A Protein
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