The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome
The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1998-07, Vol.51 (2), p.288-292 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | KORTSCHAK, R. D REIMANN, H ZIMMER, M EYRE, H. J SAINT, R JENNE, D. E |
| description | The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being expressed in a restricted set of cells including some neural cells and differentiating cells of the gut and salivary gland ducts. The mouse homolog of dri, bright, has been shown to be expressed in mature B-cells in the immune system, its product trans-activating expression through an IgH enhancer in transient transfection assays. We have cloned a human dri/bright homolog, termed DRIL1. Here we report the exon-intron structure of the gene and show physical linkage within 80 kb to the D19S886 marker on 19p13.3. As this marker is intimately linked to the Peutz-Jeghers syndrome in several large pedigrees, human dri (DRIL1) is a candidate gene for this disorder. |
| doi_str_mv | 10.1006/geno.1998.5259 |
| format | Article |
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D ; REIMANN, H ; ZIMMER, M ; EYRE, H. J ; SAINT, R ; JENNE, D. E</creator><creatorcontrib>KORTSCHAK, R. D ; REIMANN, H ; ZIMMER, M ; EYRE, H. J ; SAINT, R ; JENNE, D. E</creatorcontrib><description>The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being expressed in a restricted set of cells including some neural cells and differentiating cells of the gut and salivary gland ducts. The mouse homolog of dri, bright, has been shown to be expressed in mature B-cells in the immune system, its product trans-activating expression through an IgH enhancer in transient transfection assays. We have cloned a human dri/bright homolog, termed DRIL1. Here we report the exon-intron structure of the gene and show physical linkage within 80 kb to the D19S886 marker on 19p13.3. As this marker is intimately linked to the Peutz-Jeghers syndrome in several large pedigrees, human dri (DRIL1) is a candidate gene for this disorder.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1998.5259</identifier><identifier>PMID: 9722953</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Chromosome Mapping ; Chromosomes, Human, Pair 19 - genetics ; Cloning, Molecular ; DNA, Complementary - genetics ; DNA-Binding Proteins - genetics ; Drosophila ; Drosophila - genetics ; Drosophila Proteins ; Exons - genetics ; Fundamental and applied biological sciences. Psychology ; Genes, Regulator - genetics ; Genes. Genome ; HeLa Cells ; Homeodomain Proteins - genetics ; Humans ; Introns - genetics ; Male ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Nuclear Proteins - genetics ; Oncogenes ; Organ Specificity ; Pedigree ; Peutz-Jeghers Syndrome - genetics ; Phylogeny ; RNA, Messenger - analysis ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Trans-Activators - genetics ; Transcription Factors</subject><ispartof>Genomics (San Diego, Calif.), 1998-07, Vol.51 (2), p.288-292</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2367299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9722953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KORTSCHAK, R. D</creatorcontrib><creatorcontrib>REIMANN, H</creatorcontrib><creatorcontrib>ZIMMER, M</creatorcontrib><creatorcontrib>EYRE, H. J</creatorcontrib><creatorcontrib>SAINT, R</creatorcontrib><creatorcontrib>JENNE, D. E</creatorcontrib><title>The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being expressed in a restricted set of cells including some neural cells and differentiating cells of the gut and salivary gland ducts. The mouse homolog of dri, bright, has been shown to be expressed in mature B-cells in the immune system, its product trans-activating expression through an IgH enhancer in transient transfection assays. We have cloned a human dri/bright homolog, termed DRIL1. Here we report the exon-intron structure of the gene and show physical linkage within 80 kb to the D19S886 marker on 19p13.3. As this marker is intimately linked to the Peutz-Jeghers syndrome in several large pedigrees, human dri (DRIL1) is a candidate gene for this disorder.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 19 - genetics</subject><subject>Cloning, Molecular</subject><subject>DNA, Complementary - genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Exons - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Regulator - genetics</subject><subject>Genes. Genome</subject><subject>HeLa Cells</subject><subject>Homeodomain Proteins - genetics</subject><subject>Humans</subject><subject>Introns - genetics</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - genetics</subject><subject>Oncogenes</subject><subject>Organ Specificity</subject><subject>Pedigree</subject><subject>Peutz-Jeghers Syndrome - genetics</subject><subject>Phylogeny</subject><subject>RNA, Messenger - analysis</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Trans-Activators - genetics</subject><subject>Transcription Factors</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvClRuSD4jTZuuPxB_cqi6FohUgKOeVY88moYmd2s5h-U38SFyx4ormMNK8z8y8mkHoFSUbSoi47MCHDdVabRrW6CdoRYnSlRK1eIpWRClVyabmz9F5Sj8JIZordobOtGRMN3yFft_1gPtlMh47MA7HwXcQL9s4dH3GfZjCGLo13n673dF32G4_X2E7Bl-oNS6rAaccF5uXCGtsvMOTmeci4hzwlurvSolSL9V4DxEHj6meKd9wnHuT8ZAe2webxyMeB38P7rEvF0dfYcm_qk_Q9RALdPQuhgleoGcHMyZ4ecoX6MfN-7vrj9Xuy4fb66tdNVNFc8VBt6oFYQ-trE2tNTFMtsyZhgpNAAzXVkouhXC2cUIfCFWiHKS1DeNtiQv09u_cOYaHBVLeT0OyMI7GQ1jSXvLC10z8F6SSikYwVcDXJ3BpJ3D7OQ7lJsf96Q9Ff3PSTbJmPETj7ZD-YYwXf1rzP_v-lfM</recordid><startdate>19980715</startdate><enddate>19980715</enddate><creator>KORTSCHAK, R. D</creator><creator>REIMANN, H</creator><creator>ZIMMER, M</creator><creator>EYRE, H. J</creator><creator>SAINT, R</creator><creator>JENNE, D. E</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19980715</creationdate><title>The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome</title><author>KORTSCHAK, R. D ; REIMANN, H ; ZIMMER, M ; EYRE, H. J ; SAINT, R ; JENNE, D. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p181t-3e9b8be6cfb74a4990a27b2da51690eea39c773766dc5d69f0186722bc523b3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 19 - genetics</topic><topic>Cloning, Molecular</topic><topic>DNA, Complementary - genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Exons - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Regulator - genetics</topic><topic>Genes. Genome</topic><topic>HeLa Cells</topic><topic>Homeodomain Proteins - genetics</topic><topic>Humans</topic><topic>Introns - genetics</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - genetics</topic><topic>Oncogenes</topic><topic>Organ Specificity</topic><topic>Pedigree</topic><topic>Peutz-Jeghers Syndrome - genetics</topic><topic>Phylogeny</topic><topic>RNA, Messenger - analysis</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Trans-Activators - genetics</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KORTSCHAK, R. D</creatorcontrib><creatorcontrib>REIMANN, H</creatorcontrib><creatorcontrib>ZIMMER, M</creatorcontrib><creatorcontrib>EYRE, H. 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E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1998-07-15</date><risdate>1998</risdate><volume>51</volume><issue>2</issue><spage>288</spage><epage>292</epage><pages>288-292</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being expressed in a restricted set of cells including some neural cells and differentiating cells of the gut and salivary gland ducts. The mouse homolog of dri, bright, has been shown to be expressed in mature B-cells in the immune system, its product trans-activating expression through an IgH enhancer in transient transfection assays. We have cloned a human dri/bright homolog, termed DRIL1. Here we report the exon-intron structure of the gene and show physical linkage within 80 kb to the D19S886 marker on 19p13.3. As this marker is intimately linked to the Peutz-Jeghers syndrome in several large pedigrees, human dri (DRIL1) is a candidate gene for this disorder.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>9722953</pmid><doi>10.1006/geno.1998.5259</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 19 - genetics Cloning, Molecular DNA, Complementary - genetics DNA-Binding Proteins - genetics Drosophila Drosophila - genetics Drosophila Proteins Exons - genetics Fundamental and applied biological sciences. Psychology Genes, Regulator - genetics Genes. Genome HeLa Cells Homeodomain Proteins - genetics Humans Introns - genetics Male Molecular and cellular biology Molecular genetics Molecular Sequence Data Nuclear Proteins - genetics Oncogenes Organ Specificity Pedigree Peutz-Jeghers Syndrome - genetics Phylogeny RNA, Messenger - analysis Sequence Analysis, DNA Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Trans-Activators - genetics Transcription Factors |
| title | The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome |
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