Insulin-like growth factor I reduces thyroid hormone receptors in the rat liver. Evidence for a feed-back loop regulating the peripheral thyroid hormone action

Tri-iodothyronine (T3) is known to be involved in the regulation of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis. In previous studies we demonstrated that IGF-I and GH reduced the metabolic response to T3 measured as the activity of two T3-dependent enzymes, mitochondrial alpha-...

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Veröffentlicht in:	Journal of endocrinology 1998-07, Vol.158 (1), p.87-95
Hauptverfasser:	Pellizas, CG, Coleoni, AH, Costamagna, ME, Di Fulvio, M, Masini-Repiso, AM
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Cytosol - drug effects Cytosol - enzymology Feedback Fundamental and applied biological sciences. Psychology Glycerolphosphate Dehydrogenase - metabolism Hormones. Regulation Insulin-Like Growth Factor I - pharmacology Liver - drug effects Liver - metabolism Malate Dehydrogenase - metabolism Male Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Protein Binding Rats Rats, Wistar Receptors, Thyroid Hormone - metabolism Thyroid Hormones - metabolism Thyroid. Parathyroid. Ultimobranchial body Thyroxine - metabolism Triiodothyronine - metabolism Vertebrates: endocrinology
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