Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens
The mechanical response of the vas deferens to single pulses or short trains of stimuli can be resolved into two distinct phases, an initial twitch response ( I ) attributed to the release of an unknown transmitter and a slower better maintained secondary contraction ( II ) 1,2 , attributed to norad...
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Veröffentlicht in: | Nature (London) 1981-12, Vol.294 (5843), p.759-761 |
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container_title | Nature (London) |
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creator | Blakeley, A. G. H. Brown, D. A. Cunnane, T. C. French, A. M. McGrath, J. C. Scott, N. C. |
description | The mechanical response of the vas deferens to single pulses or short trains of stimuli can be resolved into two distinct phases, an initial twitch response (
I
) attributed to the release of an unknown transmitter and a slower better maintained secondary contraction (
II
)
1,2
, attributed to noradrenaline release. Recently, it has been shown that the calcium antagonist nifedipine
3
eliminates the initial twitch response leaving the secondary component intact
4,5
and we have now examined the electrical responses underlying these mechanical events. We show here that nifedipine abolishes the smooth muscle action potential and the initial twitch response (
I
) without reducing the excitatory junction potential (e.j.p.), suggesting a fundamentally different basis of the two responses and illustrating the pharmacological value of nifedipine. |
doi_str_mv | 10.1038/294759a0 |
format | Article |
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I
) attributed to the release of an unknown transmitter and a slower better maintained secondary contraction (
II
)
1,2
, attributed to noradrenaline release. Recently, it has been shown that the calcium antagonist nifedipine
3
eliminates the initial twitch response leaving the secondary component intact
4,5
and we have now examined the electrical responses underlying these mechanical events. We show here that nifedipine abolishes the smooth muscle action potential and the initial twitch response (
I
) without reducing the excitatory junction potential (e.j.p.), suggesting a fundamentally different basis of the two responses and illustrating the pharmacological value of nifedipine.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/294759a0</identifier><identifier>PMID: 6275272</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Guinea Pigs ; Humanities and Social Sciences ; letter ; Male ; multidisciplinary ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Nifedipine - pharmacology ; Prazosin - pharmacology ; Pyridines - pharmacology ; Rats ; Receptors, Adrenergic, alpha - drug effects ; Science ; Science (multidisciplinary) ; Vas Deferens - drug effects ; Vas Deferens - physiology</subject><ispartof>Nature (London), 1981-12, Vol.294 (5843), p.759-761</ispartof><rights>Springer Nature Limited 1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-15200b17d35c96f2a9f58b8a049044b7561a08f9c7a179051e6bd182dad97c043</citedby><cites>FETCH-LOGICAL-c378t-15200b17d35c96f2a9f58b8a049044b7561a08f9c7a179051e6bd182dad97c043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/294759a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/294759a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6275272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blakeley, A. G. H.</creatorcontrib><creatorcontrib>Brown, D. A.</creatorcontrib><creatorcontrib>Cunnane, T. C.</creatorcontrib><creatorcontrib>French, A. M.</creatorcontrib><creatorcontrib>McGrath, J. C.</creatorcontrib><creatorcontrib>Scott, N. C.</creatorcontrib><title>Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>The mechanical response of the vas deferens to single pulses or short trains of stimuli can be resolved into two distinct phases, an initial twitch response (
I
) attributed to the release of an unknown transmitter and a slower better maintained secondary contraction (
II
)
1,2
, attributed to noradrenaline release. Recently, it has been shown that the calcium antagonist nifedipine
3
eliminates the initial twitch response leaving the secondary component intact
4,5
and we have now examined the electrical responses underlying these mechanical events. We show here that nifedipine abolishes the smooth muscle action potential and the initial twitch response (
I
) without reducing the excitatory junction potential (e.j.p.), suggesting a fundamentally different basis of the two responses and illustrating the pharmacological value of nifedipine.</description><subject>Animals</subject><subject>Guinea Pigs</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Nifedipine - pharmacology</subject><subject>Prazosin - pharmacology</subject><subject>Pyridines - pharmacology</subject><subject>Rats</subject><subject>Receptors, Adrenergic, alpha - drug effects</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Vas Deferens - drug effects</subject><subject>Vas Deferens - physiology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLxDAUhYMo4zgK_gEhK9FFNUnTPJYyjA8YcKPrkKY3Y6VNa9IK_nvrzOjG1eXe79wD5yB0TskNJbm6ZZrLQltygOaUS5FxoeQhmhPCVEZULo7RSUrvhJCCSj5DM8FkwSSbI7PyHtyQcOdxqD1UdV8HwF3A0Ez3WDvbYBsq3IJ7s2G7Rkh9FxJsn6IdtnwzTn8W9_UGf9qEK_AQIaRTdORtk-BsPxfo9X71snzM1s8PT8u7deZyqYaMFoyQksoqL5wWnlntC1UqS7gmnJeyENQS5bWTlko9pQBRVlSxylZaOsLzBbrc-fax-xghDaatk4OmsQG6MRmZKyF4XkzCq53QxS6lCN70sW5t_DKUmJ8uzW-Xk_Ri7zmWLVR_wn15E7_e8TSRsIFo3rsxhinmf69v8b57Eg</recordid><startdate>19811224</startdate><enddate>19811224</enddate><creator>Blakeley, A. G. H.</creator><creator>Brown, D. A.</creator><creator>Cunnane, T. C.</creator><creator>French, A. M.</creator><creator>McGrath, J. C.</creator><creator>Scott, N. C.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19811224</creationdate><title>Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens</title><author>Blakeley, A. G. H. ; Brown, D. A. ; Cunnane, T. C. ; French, A. M. ; McGrath, J. C. ; Scott, N. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-15200b17d35c96f2a9f58b8a049044b7561a08f9c7a179051e6bd182dad97c043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Guinea Pigs</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Nifedipine - pharmacology</topic><topic>Prazosin - pharmacology</topic><topic>Pyridines - pharmacology</topic><topic>Rats</topic><topic>Receptors, Adrenergic, alpha - drug effects</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Vas Deferens - drug effects</topic><topic>Vas Deferens - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blakeley, A. G. H.</creatorcontrib><creatorcontrib>Brown, D. A.</creatorcontrib><creatorcontrib>Cunnane, T. C.</creatorcontrib><creatorcontrib>French, A. M.</creatorcontrib><creatorcontrib>McGrath, J. C.</creatorcontrib><creatorcontrib>Scott, N. C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blakeley, A. G. H.</au><au>Brown, D. A.</au><au>Cunnane, T. C.</au><au>French, A. M.</au><au>McGrath, J. C.</au><au>Scott, N. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1981-12-24</date><risdate>1981</risdate><volume>294</volume><issue>5843</issue><spage>759</spage><epage>761</epage><pages>759-761</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>The mechanical response of the vas deferens to single pulses or short trains of stimuli can be resolved into two distinct phases, an initial twitch response (
I
) attributed to the release of an unknown transmitter and a slower better maintained secondary contraction (
II
)
1,2
, attributed to noradrenaline release. Recently, it has been shown that the calcium antagonist nifedipine
3
eliminates the initial twitch response leaving the secondary component intact
4,5
and we have now examined the electrical responses underlying these mechanical events. We show here that nifedipine abolishes the smooth muscle action potential and the initial twitch response (
I
) without reducing the excitatory junction potential (e.j.p.), suggesting a fundamentally different basis of the two responses and illustrating the pharmacological value of nifedipine.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6275272</pmid><doi>10.1038/294759a0</doi><tpages>3</tpages></addata></record> |
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subjects | Animals Guinea Pigs Humanities and Social Sciences letter Male multidisciplinary Muscle Contraction - drug effects Muscle, Smooth - drug effects Nifedipine - pharmacology Prazosin - pharmacology Pyridines - pharmacology Rats Receptors, Adrenergic, alpha - drug effects Science Science (multidisciplinary) Vas Deferens - drug effects Vas Deferens - physiology |
title | Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens |
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