Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens

The mechanical response of the vas deferens to single pulses or short trains of stimuli can be resolved into two distinct phases, an initial twitch response ( I ) attributed to the release of an unknown transmitter and a slower better maintained secondary contraction ( II ) 1,2 , attributed to norad...

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Veröffentlicht in:Nature (London) 1981-12, Vol.294 (5843), p.759-761
Hauptverfasser: Blakeley, A. G. H., Brown, D. A., Cunnane, T. C., French, A. M., McGrath, J. C., Scott, N. C.
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container_end_page 761
container_issue 5843
container_start_page 759
container_title Nature (London)
container_volume 294
creator Blakeley, A. G. H.
Brown, D. A.
Cunnane, T. C.
French, A. M.
McGrath, J. C.
Scott, N. C.
description The mechanical response of the vas deferens to single pulses or short trains of stimuli can be resolved into two distinct phases, an initial twitch response ( I ) attributed to the release of an unknown transmitter and a slower better maintained secondary contraction ( II ) 1,2 , attributed to noradrenaline release. Recently, it has been shown that the calcium antagonist nifedipine 3 eliminates the initial twitch response leaving the secondary component intact 4,5 and we have now examined the electrical responses underlying these mechanical events. We show here that nifedipine abolishes the smooth muscle action potential and the initial twitch response ( I ) without reducing the excitatory junction potential (e.j.p.), suggesting a fundamentally different basis of the two responses and illustrating the pharmacological value of nifedipine.
doi_str_mv 10.1038/294759a0
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source MEDLINE; SpringerLink Journals; Nature Journals Online
subjects Animals
Guinea Pigs
Humanities and Social Sciences
letter
Male
multidisciplinary
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Nifedipine - pharmacology
Prazosin - pharmacology
Pyridines - pharmacology
Rats
Receptors, Adrenergic, alpha - drug effects
Science
Science (multidisciplinary)
Vas Deferens - drug effects
Vas Deferens - physiology
title Effects of nifedipine on electrical and mechanical responses of rat and guinea pig vas deferens
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