Effects of Losartan and Enalapril on Small Artery Structure in Hypertensive Rats
We evaluated the effects on cardiovascular structure of the angiotensin-converting enzyme (ACE) inhibitor enalapril and of the angiotensin II receptor blocker losartan, administered either at hypotensive or nonhypotensive dosage in spontaneously hypertensive rats (SHR). SHR were treated from ages 4...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998-08, Vol.32 (2), p.305-310 |
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| creator | Rizzoni, Damiano Porteri, Enzo Piccoli, Alfonso Castellano, Maurizio Bettoni, Giorgio Muiesan, Maria Lorenza Pasini, Giancarlo Guelfi, Daniele Mulvany, Michael J Rosei, Enrico Agabiti |
| description | We evaluated the effects on cardiovascular structure of the angiotensin-converting enzyme (ACE) inhibitor enalapril and of the angiotensin II receptor blocker losartan, administered either at hypotensive or nonhypotensive dosage in spontaneously hypertensive rats (SHR). SHR were treated from ages 4 to 12 weeks with low-dose (1 mg [middle dot] kg [middle dot] d) enalapril, low-dose (0.5 mg [middle dot] kg () [middle dot] d) losartan, high-dose (25 mg [middle dot] kg [middle dot] d) enalapril, or high-dose (15 mg [middle dot] kg [middle dot] d) losartan. Untreated WKY and SHR were also studied. Rats were killed at 13 weeks of age, and the heart was weighed. Mesenteric small arteries were dissected and mounted on a micromyograph for determination of media thickness and lumen diameter. In fixed arteries, cell volume, number of cells per segment length, and number of cell layers were measured using the unbiased "disector" method. Systolic blood pressure was significantly reduced by the high doses of both drugs, but the hypotensive effect was greater with enalapril than with losartan (P |
| doi_str_mv | 10.1161/01.hyp.32.2.305 |
| format | Article |
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SHR were treated from ages 4 to 12 weeks with low-dose (1 mg [middle dot] kg [middle dot] d) enalapril, low-dose (0.5 mg [middle dot] kg () [middle dot] d) losartan, high-dose (25 mg [middle dot] kg [middle dot] d) enalapril, or high-dose (15 mg [middle dot] kg [middle dot] d) losartan. Untreated WKY and SHR were also studied. Rats were killed at 13 weeks of age, and the heart was weighed. Mesenteric small arteries were dissected and mounted on a micromyograph for determination of media thickness and lumen diameter. In fixed arteries, cell volume, number of cells per segment length, and number of cell layers were measured using the unbiased "disector" method. Systolic blood pressure was significantly reduced by the high doses of both drugs, but the hypotensive effect was greater with enalapril than with losartan (P<0.05). In the high-dose enalapril and losartan groups, there were similar reductions in relative left ventricular mass, media/lumen ratio, and number of cell layers of resistance arteries; however, there were no differences in the cell volume or number of cells per segment length of resistance arteries. Low-dose enalapril did not affect systolic blood pressure or any of the structural parameters. The results show that the hypotensive effects of both losartan and enalapril were associated with outward remodeling of resistance arteries at the cellular level. The effect of losartan on resistance artery structure was equal to that of enalapril, despite the smaller hypotensive effect. (Hypertension. 1998;32:305-310.)</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.hyp.32.2.305</identifier><identifier>PMID: 9719059</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Animals ; Antihypertensive agents ; Antihypertensive Agents - administration & dosage ; Arteries - drug effects ; Arteries - pathology ; Arteries - physiopathology ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Cell Division - drug effects ; Dose-Response Relationship, Drug ; Enalapril - administration & dosage ; Heart Ventricles - drug effects ; Heart Ventricles - pathology ; Heart Ventricles - physiopathology ; Hypertension - drug therapy ; Hypertension - pathology ; Hypertension - physiopathology ; Losartan - administration & dosage ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1998-08, Vol.32 (2), p.305-310</ispartof><rights>1998 American Heart Association, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5148-9efd1bcfdafdb0acb6a1171dfd68041bd5257afa685b85e98f8b0458361d6fbb3</citedby><cites>FETCH-LOGICAL-c5148-9efd1bcfdafdb0acb6a1171dfd68041bd5257afa685b85e98f8b0458361d6fbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2363044$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9719059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizzoni, Damiano</creatorcontrib><creatorcontrib>Porteri, Enzo</creatorcontrib><creatorcontrib>Piccoli, Alfonso</creatorcontrib><creatorcontrib>Castellano, Maurizio</creatorcontrib><creatorcontrib>Bettoni, Giorgio</creatorcontrib><creatorcontrib>Muiesan, Maria Lorenza</creatorcontrib><creatorcontrib>Pasini, Giancarlo</creatorcontrib><creatorcontrib>Guelfi, Daniele</creatorcontrib><creatorcontrib>Mulvany, Michael J</creatorcontrib><creatorcontrib>Rosei, Enrico Agabiti</creatorcontrib><title>Effects of Losartan and Enalapril on Small Artery Structure in Hypertensive Rats</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>We evaluated the effects on cardiovascular structure of the angiotensin-converting enzyme (ACE) inhibitor enalapril and of the angiotensin II receptor blocker losartan, administered either at hypotensive or nonhypotensive dosage in spontaneously hypertensive rats (SHR). SHR were treated from ages 4 to 12 weeks with low-dose (1 mg [middle dot] kg [middle dot] d) enalapril, low-dose (0.5 mg [middle dot] kg () [middle dot] d) losartan, high-dose (25 mg [middle dot] kg [middle dot] d) enalapril, or high-dose (15 mg [middle dot] kg [middle dot] d) losartan. Untreated WKY and SHR were also studied. Rats were killed at 13 weeks of age, and the heart was weighed. Mesenteric small arteries were dissected and mounted on a micromyograph for determination of media thickness and lumen diameter. In fixed arteries, cell volume, number of cells per segment length, and number of cell layers were measured using the unbiased "disector" method. Systolic blood pressure was significantly reduced by the high doses of both drugs, but the hypotensive effect was greater with enalapril than with losartan (P<0.05). In the high-dose enalapril and losartan groups, there were similar reductions in relative left ventricular mass, media/lumen ratio, and number of cell layers of resistance arteries; however, there were no differences in the cell volume or number of cells per segment length of resistance arteries. Low-dose enalapril did not affect systolic blood pressure or any of the structural parameters. The results show that the hypotensive effects of both losartan and enalapril were associated with outward remodeling of resistance arteries at the cellular level. The effect of losartan on resistance artery structure was equal to that of enalapril, despite the smaller hypotensive effect. (Hypertension. 1998;32:305-310.)</description><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Arteries - drug effects</subject><subject>Arteries - pathology</subject><subject>Arteries - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Cell Division - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enalapril - administration & dosage</subject><subject>Heart Ventricles - drug effects</subject><subject>Heart Ventricles - pathology</subject><subject>Heart Ventricles - physiopathology</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Losartan - administration & dosage</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1r3DAQhkVpSLdpzz0VdCi92dFYH5aPIWy7hYWGpoXkJEaWxLrV2lvJTth_X5VdMjAMM_PMC_MS8gFYDaDgmkG9Ox5q3tRNzZl8RVYgG1EJqfhrsmLQiaoDeHhD3ub8mzEQQrSX5LJroWOyW5G7dQi-nzOdAt1OGdOMI8XR0fWIEQ9piHQa6f0eY6Q3afbpSO_ntPTzkjwdRro5HnwZj3l48vQHzvkduQgYs39_rlfk15f1z9tNtf3-9dvtzbbqJQhddT44sH1wGJxl2FuFAC244JRmAqyTjWwxoNLSauk7HbRlQmquwKlgLb8in0-6hzT9XXyezX7IvY8RRz8t2bRcK6nbpoDXJ7BPU87JB1O-2mM6GmDmv4eGgdk83hnemMYUD8vFx7P0YvfevfBn08r-03mPuccYEo79kF-whivOhCiYOGHPUyzG5T9xefbJ7DzGeWdYCdEoXUHXaaZLV5UEzf8BTaSKPg</recordid><startdate>199808</startdate><enddate>199808</enddate><creator>Rizzoni, Damiano</creator><creator>Porteri, Enzo</creator><creator>Piccoli, Alfonso</creator><creator>Castellano, Maurizio</creator><creator>Bettoni, Giorgio</creator><creator>Muiesan, Maria Lorenza</creator><creator>Pasini, Giancarlo</creator><creator>Guelfi, Daniele</creator><creator>Mulvany, Michael J</creator><creator>Rosei, Enrico Agabiti</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199808</creationdate><title>Effects of Losartan and Enalapril on Small Artery Structure in Hypertensive Rats</title><author>Rizzoni, Damiano ; Porteri, Enzo ; Piccoli, Alfonso ; Castellano, Maurizio ; Bettoni, Giorgio ; Muiesan, Maria Lorenza ; Pasini, Giancarlo ; Guelfi, Daniele ; Mulvany, Michael J ; Rosei, Enrico Agabiti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5148-9efd1bcfdafdb0acb6a1171dfd68041bd5257afa685b85e98f8b0458361d6fbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>Arteries - drug effects</topic><topic>Arteries - pathology</topic><topic>Arteries - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular system</topic><topic>Cell Division - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enalapril - administration & dosage</topic><topic>Heart Ventricles - drug effects</topic><topic>Heart Ventricles - pathology</topic><topic>Heart Ventricles - physiopathology</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>Losartan - administration & dosage</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizzoni, Damiano</creatorcontrib><creatorcontrib>Porteri, Enzo</creatorcontrib><creatorcontrib>Piccoli, Alfonso</creatorcontrib><creatorcontrib>Castellano, Maurizio</creatorcontrib><creatorcontrib>Bettoni, Giorgio</creatorcontrib><creatorcontrib>Muiesan, Maria Lorenza</creatorcontrib><creatorcontrib>Pasini, Giancarlo</creatorcontrib><creatorcontrib>Guelfi, Daniele</creatorcontrib><creatorcontrib>Mulvany, Michael J</creatorcontrib><creatorcontrib>Rosei, Enrico Agabiti</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizzoni, Damiano</au><au>Porteri, Enzo</au><au>Piccoli, Alfonso</au><au>Castellano, Maurizio</au><au>Bettoni, Giorgio</au><au>Muiesan, Maria Lorenza</au><au>Pasini, Giancarlo</au><au>Guelfi, Daniele</au><au>Mulvany, Michael J</au><au>Rosei, Enrico Agabiti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Losartan and Enalapril on Small Artery Structure in Hypertensive Rats</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1998-08</date><risdate>1998</risdate><volume>32</volume><issue>2</issue><spage>305</spage><epage>310</epage><pages>305-310</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>We evaluated the effects on cardiovascular structure of the angiotensin-converting enzyme (ACE) inhibitor enalapril and of the angiotensin II receptor blocker losartan, administered either at hypotensive or nonhypotensive dosage in spontaneously hypertensive rats (SHR). SHR were treated from ages 4 to 12 weeks with low-dose (1 mg [middle dot] kg [middle dot] d) enalapril, low-dose (0.5 mg [middle dot] kg () [middle dot] d) losartan, high-dose (25 mg [middle dot] kg [middle dot] d) enalapril, or high-dose (15 mg [middle dot] kg [middle dot] d) losartan. Untreated WKY and SHR were also studied. Rats were killed at 13 weeks of age, and the heart was weighed. Mesenteric small arteries were dissected and mounted on a micromyograph for determination of media thickness and lumen diameter. In fixed arteries, cell volume, number of cells per segment length, and number of cell layers were measured using the unbiased "disector" method. Systolic blood pressure was significantly reduced by the high doses of both drugs, but the hypotensive effect was greater with enalapril than with losartan (P<0.05). In the high-dose enalapril and losartan groups, there were similar reductions in relative left ventricular mass, media/lumen ratio, and number of cell layers of resistance arteries; however, there were no differences in the cell volume or number of cells per segment length of resistance arteries. Low-dose enalapril did not affect systolic blood pressure or any of the structural parameters. The results show that the hypotensive effects of both losartan and enalapril were associated with outward remodeling of resistance arteries at the cellular level. The effect of losartan on resistance artery structure was equal to that of enalapril, despite the smaller hypotensive effect. (Hypertension. 1998;32:305-310.)</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>9719059</pmid><doi>10.1161/01.hyp.32.2.305</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 1998-08, Vol.32 (2), p.305-310 |
| issn | 0194-911X 1524-4563 |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antihypertensive agents Antihypertensive Agents - administration & dosage Arteries - drug effects Arteries - pathology Arteries - physiopathology Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Cell Division - drug effects Dose-Response Relationship, Drug Enalapril - administration & dosage Heart Ventricles - drug effects Heart Ventricles - pathology Heart Ventricles - physiopathology Hypertension - drug therapy Hypertension - pathology Hypertension - physiopathology Losartan - administration & dosage Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred SHR Rats, Inbred WKY |
| title | Effects of Losartan and Enalapril on Small Artery Structure in Hypertensive Rats |
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