99mTc-ENS, a New Radiopharmaceutical for Aerial Lung Scintigraphy: Comparative Studies in Rats

99mTc-ENS, a New Radiopharmaceutical for Aerial Lung Scintigraphy: Comparative Studies in Rats

The biological behavior of 99mTc-labeled exogenous natural surfactant ( 99mTc-ENS) was studied and compared to 99mTc-diethylenetriaminepentaacetate ( 99mTc-DTPA) and 99mTcO 4 −. The labeling yield percentages for 99mTc-DTPA and 99mTc-ENS were higher than 95%. Biodistribution studies performed after...

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Veröffentlicht in:Nuclear medicine and biology 1998-07, Vol.25 (5), p.511-513
Hauptverfasser: Calmanovici, G, Zubillaga, M, Lysionek, A, Hager, A, De Paoli, T, Alak, M, Degrossi, O, Garcia del Rio, H, Nicolini, J, Caro, R, Boccio, J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Contrast media. Radiopharmaceuticals
Female
Lung - diagnostic imaging
Lung - metabolism
Medical sciences
Organotechnetium Compounds
Pharmacology. Drug treatments
Quality Control
Radionuclide Imaging
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - pharmacology
Rats
Rats, Sprague-Dawley
Technetium Tc 99m Pentetate
Tissue Distribution
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Zusammenfassung:The biological behavior of 99mTc-labeled exogenous natural surfactant ( 99mTc-ENS) was studied and compared to 99mTc-diethylenetriaminepentaacetate ( 99mTc-DTPA) and 99mTcO 4 −. The labeling yield percentages for 99mTc-DTPA and 99mTc-ENS were higher than 95%. Biodistribution studies performed after aerosolization showed that the percentage of activity concentration in lungs for 99mTc-ENS was 98.7 ± 1.3%, for 99mTc-DTPA 77.8 ± 20.6%, and 22.4 ± 7.5% in the case of 99mTcO 4 −. These results suggest that this new radiopharmaceutical shows an optimal lung concentration, and therefore it can be considered for clinical trials.
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(98)00013-4