Impaired glycolysis of human lymphocytes during aging
When peripheral lymphocytes from young persons are stimulated in vitro with phytohemagglutinin, an increase in the levels of all the glycolytic enzymes occurs concomitantly with blastogenesis. The specific activities of enzymes increase approximately 200%, with a greater induction of the latter half...
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| Veröffentlicht in: | Mechanisms of ageing and development 1981-01, Vol.17 (4), p.369-379 |
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| container_title | Mechanisms of ageing and development |
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| creator | Tollefsbol, Trygve O. Chapman, M.Lynne Zaun, M.Rebecca Gracy, Robert W. |
| description | When peripheral lymphocytes from young persons are stimulated
in vitro with phytohemagglutinin, an increase in the levels of all the glycolytic enzymes occurs concomitantly with blastogenesis. The specific activities of enzymes increase approximately 200%, with a greater induction of the latter half of the pathway. The increases do not represent a general enzyme induction, since nonglycolytic enzymes such as glucose 6-phosphate dehydrogenase and isocitrate dehydrogenase do not increase during transformation.
Human lymphocytes from a geriatric population were also subjected to mitogen stimulation under identical conditions. The initial levels of the enzymes were essentially identical in lymphocytes from young and old subjects as were cultured controls which received no mitogen. However, during mitogen stimulation the cells from the old subjects failed to incrase the glycolytic enzymes. This inability to activate glycolysis may be related to the decline in cell-mediated immunity which is known to occur with advacing age. |
| doi_str_mv | 10.1016/0047-6374(81)90054-3 |
| format | Article |
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in vitro with phytohemagglutinin, an increase in the levels of all the glycolytic enzymes occurs concomitantly with blastogenesis. The specific activities of enzymes increase approximately 200%, with a greater induction of the latter half of the pathway. The increases do not represent a general enzyme induction, since nonglycolytic enzymes such as glucose 6-phosphate dehydrogenase and isocitrate dehydrogenase do not increase during transformation.
Human lymphocytes from a geriatric population were also subjected to mitogen stimulation under identical conditions. The initial levels of the enzymes were essentially identical in lymphocytes from young and old subjects as were cultured controls which received no mitogen. However, during mitogen stimulation the cells from the old subjects failed to incrase the glycolytic enzymes. This inability to activate glycolysis may be related to the decline in cell-mediated immunity which is known to occur with advacing age.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/0047-6374(81)90054-3</identifier><identifier>PMID: 7329102</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Aging ; Cells, Cultured ; Glucosephosphate Dehydrogenase - blood ; Glycolysis ; Humans ; Isocitrate Dehydrogenase - blood ; Lymphocyte Activation ; Lymphocytes - enzymology ; Phytohemagglutinins - pharmacology</subject><ispartof>Mechanisms of ageing and development, 1981-01, Vol.17 (4), p.369-379</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-7cd52d3d86e3e6cc0cd2de47f375de05149b662453a9ef8870069934a140d3c3</citedby><cites>FETCH-LOGICAL-c388t-7cd52d3d86e3e6cc0cd2de47f375de05149b662453a9ef8870069934a140d3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0047-6374(81)90054-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7329102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tollefsbol, Trygve O.</creatorcontrib><creatorcontrib>Chapman, M.Lynne</creatorcontrib><creatorcontrib>Zaun, M.Rebecca</creatorcontrib><creatorcontrib>Gracy, Robert W.</creatorcontrib><title>Impaired glycolysis of human lymphocytes during aging</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>When peripheral lymphocytes from young persons are stimulated
in vitro with phytohemagglutinin, an increase in the levels of all the glycolytic enzymes occurs concomitantly with blastogenesis. The specific activities of enzymes increase approximately 200%, with a greater induction of the latter half of the pathway. The increases do not represent a general enzyme induction, since nonglycolytic enzymes such as glucose 6-phosphate dehydrogenase and isocitrate dehydrogenase do not increase during transformation.
Human lymphocytes from a geriatric population were also subjected to mitogen stimulation under identical conditions. The initial levels of the enzymes were essentially identical in lymphocytes from young and old subjects as were cultured controls which received no mitogen. However, during mitogen stimulation the cells from the old subjects failed to incrase the glycolytic enzymes. This inability to activate glycolysis may be related to the decline in cell-mediated immunity which is known to occur with advacing age.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Cells, Cultured</subject><subject>Glucosephosphate Dehydrogenase - blood</subject><subject>Glycolysis</subject><subject>Humans</subject><subject>Isocitrate Dehydrogenase - blood</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes - enzymology</subject><subject>Phytohemagglutinins - pharmacology</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRaq3-A4WcRA_R2Y_sbi6CFD8KBS-9L-nupF3Jl9lGyL83saVHvcwc3mfegYeQawoPFKh8BBAqllyJO03vU4BExPyETKlWLJaMylMyPSLn5CKETwCggskJmSjOUgpsSpJF2WS-RRdtit7WRR98iOo82nZlVkVFXzbb2vY7DJHrWl9tomwzzEtylmdFwKvDnpHV68tq_h4vP94W8-dlbLnWu1hZlzDHnZbIUVoL1jGHQuVcJQ4hoSJdS8lEwrMUc60VgExTLjIqwHHLZ-R2X9u09VeHYWdKHywWRVZh3QWjuJYAnP8L0kSwhHE9gGIP2rYOocXcNK0vs7Y3FMxo1YzKzKjMaGp-rZqx_-bQ361LdMejg8Yhf9rnOMj49tiaYD1WFt2g1u6Mq_3fD34ANn-FHw</recordid><startdate>19810101</startdate><enddate>19810101</enddate><creator>Tollefsbol, Trygve O.</creator><creator>Chapman, M.Lynne</creator><creator>Zaun, M.Rebecca</creator><creator>Gracy, Robert W.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19810101</creationdate><title>Impaired glycolysis of human lymphocytes during aging</title><author>Tollefsbol, Trygve O. ; Chapman, M.Lynne ; Zaun, M.Rebecca ; Gracy, Robert W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-7cd52d3d86e3e6cc0cd2de47f375de05149b662453a9ef8870069934a140d3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Cells, Cultured</topic><topic>Glucosephosphate Dehydrogenase - blood</topic><topic>Glycolysis</topic><topic>Humans</topic><topic>Isocitrate Dehydrogenase - blood</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - enzymology</topic><topic>Phytohemagglutinins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tollefsbol, Trygve O.</creatorcontrib><creatorcontrib>Chapman, M.Lynne</creatorcontrib><creatorcontrib>Zaun, M.Rebecca</creatorcontrib><creatorcontrib>Gracy, Robert W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tollefsbol, Trygve O.</au><au>Chapman, M.Lynne</au><au>Zaun, M.Rebecca</au><au>Gracy, Robert W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired glycolysis of human lymphocytes during aging</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>1981-01-01</date><risdate>1981</risdate><volume>17</volume><issue>4</issue><spage>369</spage><epage>379</epage><pages>369-379</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><abstract>When peripheral lymphocytes from young persons are stimulated
in vitro with phytohemagglutinin, an increase in the levels of all the glycolytic enzymes occurs concomitantly with blastogenesis. The specific activities of enzymes increase approximately 200%, with a greater induction of the latter half of the pathway. The increases do not represent a general enzyme induction, since nonglycolytic enzymes such as glucose 6-phosphate dehydrogenase and isocitrate dehydrogenase do not increase during transformation.
Human lymphocytes from a geriatric population were also subjected to mitogen stimulation under identical conditions. The initial levels of the enzymes were essentially identical in lymphocytes from young and old subjects as were cultured controls which received no mitogen. However, during mitogen stimulation the cells from the old subjects failed to incrase the glycolytic enzymes. This inability to activate glycolysis may be related to the decline in cell-mediated immunity which is known to occur with advacing age.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>7329102</pmid><doi>10.1016/0047-6374(81)90054-3</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0047-6374 |
| ispartof | Mechanisms of ageing and development, 1981-01, Vol.17 (4), p.369-379 |
| issn | 0047-6374 1872-6216 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Aging Cells, Cultured Glucosephosphate Dehydrogenase - blood Glycolysis Humans Isocitrate Dehydrogenase - blood Lymphocyte Activation Lymphocytes - enzymology Phytohemagglutinins - pharmacology |
| title | Impaired glycolysis of human lymphocytes during aging |
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