Dopamine and nicotinic receptor binding and the levels of dopamine and homovanillic acid in human brain related to tobacco use

Reports of a reduction in the risk of developing Parkinson's disease and Alzheimer's disease in tobacco smokers, together with the loss of high-affinity nicotine binding in these diseases, suggest that consequences of nicotinic cholinergic transmission may be neuroprotective. Changes in br...

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Veröffentlicht in:	Neuroscience 1998-11, Vol.87 (1), p.63-78
Hauptverfasser:	Court, J.A, Lloyd, S, Thomas, N, Piggott, M.A, Marshall, E.F, Morris, C.M, Lamb, H, Perry, R.H, Johnson, M, Perry, E.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over apolipoprotein E Apolipoproteins E - genetics Biological and medical sciences Brain - anatomy & histology Brain - metabolism Bungarotoxins - metabolism Carrier Proteins - metabolism Cerebellum - metabolism Corpus Striatum - metabolism Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins dopamine receptors dopamine turnover Female Hippocampus - metabolism Homovanillic Acid - metabolism human brain Humans Male Medical sciences Membrane Glycoproteins Membrane Transport Proteins Middle Aged Nerve Tissue Proteins nicotinic receptors Receptors, Dopamine - metabolism Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 Receptors, Nicotinic - metabolism Sex Factors Smoking - metabolism tobacco smoking Tobacco, tobacco smoking Toxicology
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