Up-regulation of Vascular Endothelial Growth Factor Induced by Hepatocyte Growth Factor/Scatter Factor Stimulation in Human Glioma Cells
Recent findings suggest that hepatocyte growth factor/scatter factor (HGF/SF) contributes to the malignant progression of human gliomas. We investigated the effect of HGF/SF on vascular endothelial growth factor (VEGF) expression of c-Met/HGF receptor-positive human glioma cell lines. Treatment of t...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1998-08, Vol.249 (1), p.73-77 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Moriyama, Takuzou Kataoka, Hiroaki Hamasuna, Ryoichi Yokogami, Kiyotaka Uehara, Hisao Kawano, Hirokazu Goya, Tomokazu Tsubouchi, Hirohito Koono, Masashi Wakisaka, Shinichiro |
| description | Recent findings suggest that hepatocyte growth factor/scatter factor (HGF/SF) contributes to the malignant progression of human gliomas. We investigated the effect of HGF/SF on vascular endothelial growth factor (VEGF) expression of c-Met/HGF receptor-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of VEGF proteins accompanying increased transcription of VEGF mRNA in a dose-dependent fashion. Since malignant gliomas frequently co-express HGF/SF and its receptor, these results suggest that HGF/SF could act as an indirect angiogenic factor through autocrine induction of VEGF expression and secretion in malignant gliomas. |
| doi_str_mv | 10.1006/bbrc.1998.9078 |
| format | Article |
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| ispartof | Biochemical and biophysical research communications, 1998-08, Vol.249 (1), p.73-77 |
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| subjects | Endothelial Growth Factors - biosynthesis Glioma - metabolism Hepatocyte Growth Factor - pharmacology Humans Lymphokines - biosynthesis Tumor Cells, Cultured Up-Regulation - drug effects Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| title | Up-regulation of Vascular Endothelial Growth Factor Induced by Hepatocyte Growth Factor/Scatter Factor Stimulation in Human Glioma Cells |
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