Proactive interference and temporal context encoding after diazepam intake

Two experiments were designed to test whether the memory impairment induced by benzodiazepines (BZDs) is due to impaired memory for temporal context. In both experiments, subjects were administered either diazepam (15 mg oral) or placebo, and a standard BZD impairment on prose recall as well as a de...

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Veröffentlicht in:Psychopharmacology 1998-08, Vol.138 (3-4), p.334-343
Hauptverfasser: Gorissen, M E, Curran, H V, Eling, P A
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creator Gorissen, M E
Curran, H V
Eling, P A
description Two experiments were designed to test whether the memory impairment induced by benzodiazepines (BZDs) is due to impaired memory for temporal context. In both experiments, subjects were administered either diazepam (15 mg oral) or placebo, and a standard BZD impairment on prose recall as well as a decreased subjective arousal was found. Key tasks to explore temporal context memory were an A-B A-C proactive interference paradigm and a list discrimination task. Initial learning of both groups on these tasks was broadly matched. In experiment 1, diazepam did not increase susceptibility to proactive interference using semantically related words. However, in experiment 2, using unrelated word pairs, diazepam markedly increased the number of prior list intrusions. Furthermore, after diazepam intake, subjects were clearly impaired in learning unrelated word pairs. Subjects after diazepam intake were not impaired in the list discrimination task. We conclude that (1) diazepam impairs the forming of new associations, whether this is the formation of links between two or more targets or between targets and context, (2) a temporal context encoding deficit cannot account for a broader diazepam-induced memory impairment.
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subjects Adult
Affect
Arousal
Benzodiazepines
Diazepam
Diazepam - pharmacology
Discrimination (Psychology) - drug effects
Double-Blind Method
Female
Humans
Learning
Male
Memory - drug effects
Mental task performance
Proactive interference
Psychomotor Performance - drug effects
title Proactive interference and temporal context encoding after diazepam intake
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