Gastrointestinal perforation early after peripheral blood stem cell transplantation for AL amyloidosis
The morbidity and mortality of AL amyloidosis is caused by the deposition of Ig light chains as amyloid protein in vital organs. With conventional therapy median survival of patients with AL amyloidosis is 10-14 months. With high-dose chemotherapy clinical remissions of organ-specific disease have b...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 1998-08, Vol.22 (3), p.293-295 |
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| creator | SCHULENBURG, A KALHS, P OBERHUBER, G REITER, E BASE, W GREINIX, H |
| description | The morbidity and mortality of AL amyloidosis is caused by the deposition of Ig light chains as amyloid protein in vital organs. With conventional therapy median survival of patients with AL amyloidosis is 10-14 months. With high-dose chemotherapy clinical remissions of organ-specific disease have been reported. Here, we present a patient with high-risk AL amyloidosis who was given high-dose therapy and a peripheral blood stem cell transplant. Four days later she died of gastrointestinal perforation due to amyloid infiltrations. |
| doi_str_mv | 10.1038/sj.bmt.1701330 |
| format | Article |
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With conventional therapy median survival of patients with AL amyloidosis is 10-14 months. With high-dose chemotherapy clinical remissions of organ-specific disease have been reported. Here, we present a patient with high-risk AL amyloidosis who was given high-dose therapy and a peripheral blood stem cell transplant. 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Four days later she died of gastrointestinal perforation due to amyloid infiltrations.</description><subject>Adult</subject><subject>Amyloid</subject><subject>Amyloidosis</subject><subject>Amyloidosis - immunology</subject><subject>Amyloidosis - pathology</subject><subject>Amyloidosis - therapy</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Chemotherapy</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Immunoglobulin lambda-Chains - metabolism</subject><subject>Immunoglobulins</subject><subject>Intestinal Perforation - etiology</subject><subject>Intestinal Perforation - immunology</subject><subject>Intestinal Perforation - pathology</subject><subject>Light chains</subject><subject>Medical sciences</subject><subject>Morbidity</subject><subject>Organs</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transplantation</subject><subject>Transplantation, Autologous</subject><subject>Transplants & implants</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtr3DAURkVoSSdpt9kFDA3Zeaq37GUIecFANu1ayLJENMiWq6tZzL-vhjFZdCW493wXfQehG4K3BLPuF-y3w1S2RGHCGL5AG8KVbAWT4gvaYCq7ljHZf0NXAHuMCedYXKLLXlGsuNwg_2Kg5BTm4qCE2cRmcdmnbEpIc-NMjsfG-OLyaR6WD5crMsSUxgaKmxrrYmxKNjMs0czlHKv55mHXmOkYUxgTBPiOvnoTwf1Y32v05_np9-Nru3t_eXt82LWWcVVaT0YrOKnFuODCY9wNYlDWjwR3rhsMdrTzpKcjJYooSUbWSzlYJXBvubeKXaP7890lp7-HWklPAU5_NLNLB9CKdYIJyiv48z9wnw659gdNJadEYCVFpbZnyuYEkJ3XSw6TyUdNsD7p17DXVb9e9dfA7Xr2MExu_MRX33V_t-4NWBN9FWcDfGKUUdoJxf4BxLeO2Q</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>SCHULENBURG, A</creator><creator>KALHS, P</creator><creator>OBERHUBER, G</creator><creator>REITER, E</creator><creator>BASE, W</creator><creator>GREINIX, H</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Gastrointestinal perforation early after peripheral blood stem cell transplantation for AL amyloidosis</title><author>SCHULENBURG, A ; KALHS, P ; OBERHUBER, G ; REITER, E ; BASE, W ; GREINIX, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-f1dc5411034545f008b5b7cfd108e8ba0e28f192d2171761d3966bc7509c4fc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Amyloid</topic><topic>Amyloidosis</topic><topic>Amyloidosis - immunology</topic><topic>Amyloidosis - pathology</topic><topic>Amyloidosis - therapy</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Chemotherapy</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Immunoglobulin lambda-Chains - metabolism</topic><topic>Immunoglobulins</topic><topic>Intestinal Perforation - etiology</topic><topic>Intestinal Perforation - immunology</topic><topic>Intestinal Perforation - pathology</topic><topic>Light chains</topic><topic>Medical sciences</topic><topic>Morbidity</topic><topic>Organs</topic><topic>Patients</topic><topic>Peripheral blood</topic><topic>Pharmacology. 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| ispartof | Bone marrow transplantation (Basingstoke), 1998-08, Vol.22 (3), p.293-295 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Amyloid Amyloidosis Amyloidosis - immunology Amyloidosis - pathology Amyloidosis - therapy Antineoplastic agents Biological and medical sciences Blood Chemotherapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Fatal Outcome Female Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Immunoglobulin lambda-Chains - metabolism Immunoglobulins Intestinal Perforation - etiology Intestinal Perforation - immunology Intestinal Perforation - pathology Light chains Medical sciences Morbidity Organs Patients Peripheral blood Pharmacology. Drug treatments Stem cell transplantation Stem cells Transplantation Transplantation, Autologous Transplants & implants |
| title | Gastrointestinal perforation early after peripheral blood stem cell transplantation for AL amyloidosis |
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