Oxatomide in the management of hay fever-a placebo-controlled double-blind study in general practice
Summary Sixty‐three patients completed a double‐blind placebo‐controlled study of oral oxatomide (30 mg t.d.s.) in the management of seasonal allergic rhinitis and/or conjunctivitis. Hay fever symptom scores were significantly lower for oxatomide‐treated patients than for the placebo group on the ma...
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| Veröffentlicht in: | Clinical allergy 1981-09, Vol.11 (5), p.491-497 |
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| container_issue | 5 |
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| container_title | Clinical allergy |
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| creator | WOOD, S. F. BARBER, J. H. |
| description | Summary
Sixty‐three patients completed a double‐blind placebo‐controlled study of oral oxatomide (30 mg t.d.s.) in the management of seasonal allergic rhinitis and/or conjunctivitis. Hay fever symptom scores were significantly lower for oxatomide‐treated patients than for the placebo group on the majority of days during periods of high pollen counts. Moreover, on days when pollen counts were 10/m3 or more, a statistically significant positive correlation between symptom score and pollen count was demonstrated for the placebo group but not for the oxatomide group. Oxatomide also appeared to be superior to placebo in terms of patients' requirements for supplementary mepyramine (Anthisan) tablets, and the doctor's global assessment. Side‐effects were reported by four patients in the oxatomide group and by three receiving placebo. |
| doi_str_mv | 10.1111/j.1365-2222.1981.tb01624.x |
| format | Article |
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Sixty‐three patients completed a double‐blind placebo‐controlled study of oral oxatomide (30 mg t.d.s.) in the management of seasonal allergic rhinitis and/or conjunctivitis. Hay fever symptom scores were significantly lower for oxatomide‐treated patients than for the placebo group on the majority of days during periods of high pollen counts. Moreover, on days when pollen counts were 10/m3 or more, a statistically significant positive correlation between symptom score and pollen count was demonstrated for the placebo group but not for the oxatomide group. Oxatomide also appeared to be superior to placebo in terms of patients' requirements for supplementary mepyramine (Anthisan) tablets, and the doctor's global assessment. Side‐effects were reported by four patients in the oxatomide group and by three receiving placebo.</description><identifier>ISSN: 0954-7894</identifier><identifier>ISSN: 0009-9090</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.1981.tb01624.x</identifier><identifier>PMID: 6119170</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Adolescent ; Adult ; Child ; Clinical Trials as Topic ; Double-Blind Method ; Female ; Histamine H1 Antagonists - therapeutic use ; Humans ; Male ; Middle Aged ; Piperazines - therapeutic use ; Placebos ; Pollen ; Random Allocation ; Rhinitis, Allergic, Seasonal - drug therapy</subject><ispartof>Clinical allergy, 1981-09, Vol.11 (5), p.491-497</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5081-2eba1a6a0c213820a865fa0d57441833124d51decbc9f45afc0205b2285f96053</citedby><cites>FETCH-LOGICAL-c5081-2eba1a6a0c213820a865fa0d57441833124d51decbc9f45afc0205b2285f96053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.1981.tb01624.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.1981.tb01624.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6119170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WOOD, S. F.</creatorcontrib><creatorcontrib>BARBER, J. H.</creatorcontrib><title>Oxatomide in the management of hay fever-a placebo-controlled double-blind study in general practice</title><title>Clinical allergy</title><addtitle>Clin Allergy</addtitle><description>Summary
Sixty‐three patients completed a double‐blind placebo‐controlled study of oral oxatomide (30 mg t.d.s.) in the management of seasonal allergic rhinitis and/or conjunctivitis. Hay fever symptom scores were significantly lower for oxatomide‐treated patients than for the placebo group on the majority of days during periods of high pollen counts. Moreover, on days when pollen counts were 10/m3 or more, a statistically significant positive correlation between symptom score and pollen count was demonstrated for the placebo group but not for the oxatomide group. Oxatomide also appeared to be superior to placebo in terms of patients' requirements for supplementary mepyramine (Anthisan) tablets, and the doctor's global assessment. Side‐effects were reported by four patients in the oxatomide group and by three receiving placebo.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Histamine H1 Antagonists - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Piperazines - therapeutic use</subject><subject>Placebos</subject><subject>Pollen</subject><subject>Random Allocation</subject><subject>Rhinitis, Allergic, Seasonal - drug therapy</subject><issn>0954-7894</issn><issn>0009-9090</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkUFv1DAQhS1EVbaFn4BkceCW4LHjxOGAVC2lpapaIS1wtBx70mZxkq2dwO6_J9Gu9lp1LnN4b76R3iPkA7AUpvm0TkHkMuHTpFAqSIeKQc6zdPuKLI7Sa7JgpcySQpXZG3IW45oxJmSpTslpDlBCwRbE3W_N0LeNQ9p0dHhE2prOPGCL3UD7mj6aHa3xL4bE0I03Fqs-sX03hN57dNT1Y-UxqXzTORqH0e1mzAN2GIynm2Ds0Fh8S05q4yO-O-xz8vPb5Wp5ndzeX31fXtwmVjIFCcfKgMkNsxyE4syoXNaGOVlkGSghgGdOgkNb2bLOpKkt40xWnCtZlzmT4px83HM3oX8aMQ66baJF702H_Rh1IZTkUuTPGkEKrriajZ_3Rhv6GAPWehOa1oSdBqbnLvRaz4HrOXA9d6EPXejtdPz-8GWsWnTH00P4k_5lr_9rPO5eQNbLy4ushAmQ7AFNHHB7BJjwR-eFKKT-fXelf92slj9gdae_iv9Pzqh0</recordid><startdate>198109</startdate><enddate>198109</enddate><creator>WOOD, S. F.</creator><creator>BARBER, J. H.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198109</creationdate><title>Oxatomide in the management of hay fever-a placebo-controlled double-blind study in general practice</title><author>WOOD, S. F. ; BARBER, J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5081-2eba1a6a0c213820a865fa0d57441833124d51decbc9f45afc0205b2285f96053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Histamine H1 Antagonists - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Piperazines - therapeutic use</topic><topic>Placebos</topic><topic>Pollen</topic><topic>Random Allocation</topic><topic>Rhinitis, Allergic, Seasonal - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WOOD, S. F.</creatorcontrib><creatorcontrib>BARBER, J. H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WOOD, S. F.</au><au>BARBER, J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxatomide in the management of hay fever-a placebo-controlled double-blind study in general practice</atitle><jtitle>Clinical allergy</jtitle><addtitle>Clin Allergy</addtitle><date>1981-09</date><risdate>1981</risdate><volume>11</volume><issue>5</issue><spage>491</spage><epage>497</epage><pages>491-497</pages><issn>0954-7894</issn><issn>0009-9090</issn><eissn>1365-2222</eissn><abstract>Summary
Sixty‐three patients completed a double‐blind placebo‐controlled study of oral oxatomide (30 mg t.d.s.) in the management of seasonal allergic rhinitis and/or conjunctivitis. Hay fever symptom scores were significantly lower for oxatomide‐treated patients than for the placebo group on the majority of days during periods of high pollen counts. Moreover, on days when pollen counts were 10/m3 or more, a statistically significant positive correlation between symptom score and pollen count was demonstrated for the placebo group but not for the oxatomide group. Oxatomide also appeared to be superior to placebo in terms of patients' requirements for supplementary mepyramine (Anthisan) tablets, and the doctor's global assessment. Side‐effects were reported by four patients in the oxatomide group and by three receiving placebo.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6119170</pmid><doi>10.1111/j.1365-2222.1981.tb01624.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical allergy, 1981-09, Vol.11 (5), p.491-497 |
| issn | 0954-7894 0009-9090 1365-2222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73852536 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Administration, Oral Adolescent Adult Child Clinical Trials as Topic Double-Blind Method Female Histamine H1 Antagonists - therapeutic use Humans Male Middle Aged Piperazines - therapeutic use Placebos Pollen Random Allocation Rhinitis, Allergic, Seasonal - drug therapy |
| title | Oxatomide in the management of hay fever-a placebo-controlled double-blind study in general practice |
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