Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogs: potent angiotensin converting enzyme inhibitors

A new approach was developed for the synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline (1) and 23 analogues. The delta-(acylamino)-gamma-keto acid intermediates were obtained by a modified Dakin--West reaction using 3-carbomethoxypropionyl chloride. Acylation of L-proline and r...

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Veröffentlicht in:	Journal of medicinal chemistry 1981-08, Vol.24 (8), p.964-969
Hauptverfasser:	Meyer, Robert F, Nicolaides, Ernest D, Tinney, Francis G, Lunney, Elizabeth A, Holmes, Ann, Hoefle, Milton L, Smith, Ronald D, Essenburg, Arnold D, Kaplan, Harvey R, Almquist, Ronald G
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Blood Pressure - drug effects Dipeptides - chemical synthesis Dipeptides - pharmacology Dose-Response Relationship, Drug Male Oligopeptides Rats Structure-Activity Relationship Teprotide
Online-Zugang:	Volltext
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