Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein

Resistance against the antitumor drug cis-dichlorodiammineplatinum ( cis-DDP) was tested in cultured cells: one human epithelial line derived from normal skin (HE), one mouse fibroblast line derived from L cells (Cl lD), as well as Cd-resistant substrains of both cell lines (designated HE 100 and Cl...

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Veröffentlicht in:	Toxicology and applied pharmacology 1981-11, Vol.61 (2), p.215-226
Hauptverfasser:	Bakka, Arne, Endresen, Liv, Johnsen, Alf B.S., Edminson, Paul D., Rugstad, Hans Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Cell Line Cisplatin - metabolism Cisplatin - pharmacology Drug Resistance Humans Metalloproteins - physiology Metallothionein - physiology Mice
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