Role of placenta in maternal-fetal vitamin transfer in humans
Vitamins B12, B6, biotin, folate, thiamine, riboflavin, pantothenate, and nicotinate were determined in maternal and fetal blood and placental tissue of normovitaminemic and hypovitaminemic mothers who disclaimed supplemental vitamin intake during pregnancy. No biotin or pantothenate deficits were o...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1981-12, Vol.141 (7), p.792-796 |
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| container_end_page | 796 |
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| container_issue | 7 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 141 |
| creator | Baker, Herman Frank, Oscar Deangelis, Barbara Feingold, Susan Kaminetzky, Harold A. |
| description | Vitamins B12, B6, biotin, folate, thiamine, riboflavin, pantothenate, and nicotinate were determined in maternal and fetal blood and placental tissue of normovitaminemic and hypovitaminemic mothers who disclaimed supplemental vitamin intake during pregnancy. No biotin or pantothenate deficits were observed in the gravidas. Hypovitaminemic mothers transferred less B12, folate, and B6 to the fetus and placenta than normovitaminemic mothers. Vitamins given by mouth increased maternal, fetal, and placental levels of folate, but B6 increased only in maternal blood and the placenta; biotin and pantothenate increased only in fetal blood. Except for riboflavin, nicotinate, and pantothenate, the intramuscular administration of vitamins increased the levels of other vitamins in maternal and fetal blood and placental tissue. Results suggest that the placenta stores vitamins and that tissue vitamin receptors must be saturated before adequate transfer of vitamins to the fetus occurs. |
| doi_str_mv | 10.1016/0002-9378(81)90706-7 |
| format | Article |
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No biotin or pantothenate deficits were observed in the gravidas. Hypovitaminemic mothers transferred less B12, folate, and B6 to the fetus and placenta than normovitaminemic mothers. Vitamins given by mouth increased maternal, fetal, and placental levels of folate, but B6 increased only in maternal blood and the placenta; biotin and pantothenate increased only in fetal blood. Except for riboflavin, nicotinate, and pantothenate, the intramuscular administration of vitamins increased the levels of other vitamins in maternal and fetal blood and placental tissue. Results suggest that the placenta stores vitamins and that tissue vitamin receptors must be saturated before adequate transfer of vitamins to the fetus occurs.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(81)90706-7</identifier><identifier>PMID: 7198383</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Biotin - physiology ; Female ; Folic Acid - physiology ; Humans ; Maternal-Fetal Exchange ; Nicotinic Acids - physiology ; Pantothenic Acid - physiology ; Placenta - physiology ; Pregnancy ; Pyridoxine - physiology ; Riboflavin - physiology ; Thiamine - physiology ; Vitamin B 12 - physiology ; Vitamins - blood ; Vitamins - physiology</subject><ispartof>American journal of obstetrics and gynecology, 1981-12, Vol.141 (7), p.792-796</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-78896b45c2c3bf5deac8eba4763f8c959d91016026349750f846e7381d68b783</citedby><cites>FETCH-LOGICAL-c357t-78896b45c2c3bf5deac8eba4763f8c959d91016026349750f846e7381d68b783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(81)90706-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7198383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baker, Herman</creatorcontrib><creatorcontrib>Frank, Oscar</creatorcontrib><creatorcontrib>Deangelis, Barbara</creatorcontrib><creatorcontrib>Feingold, Susan</creatorcontrib><creatorcontrib>Kaminetzky, Harold A.</creatorcontrib><title>Role of placenta in maternal-fetal vitamin transfer in humans</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Vitamins B12, B6, biotin, folate, thiamine, riboflavin, pantothenate, and nicotinate were determined in maternal and fetal blood and placental tissue of normovitaminemic and hypovitaminemic mothers who disclaimed supplemental vitamin intake during pregnancy. No biotin or pantothenate deficits were observed in the gravidas. Hypovitaminemic mothers transferred less B12, folate, and B6 to the fetus and placenta than normovitaminemic mothers. Vitamins given by mouth increased maternal, fetal, and placental levels of folate, but B6 increased only in maternal blood and the placenta; biotin and pantothenate increased only in fetal blood. Except for riboflavin, nicotinate, and pantothenate, the intramuscular administration of vitamins increased the levels of other vitamins in maternal and fetal blood and placental tissue. Results suggest that the placenta stores vitamins and that tissue vitamin receptors must be saturated before adequate transfer of vitamins to the fetus occurs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biotin - physiology</subject><subject>Female</subject><subject>Folic Acid - physiology</subject><subject>Humans</subject><subject>Maternal-Fetal Exchange</subject><subject>Nicotinic Acids - physiology</subject><subject>Pantothenic Acid - physiology</subject><subject>Placenta - physiology</subject><subject>Pregnancy</subject><subject>Pyridoxine - physiology</subject><subject>Riboflavin - physiology</subject><subject>Thiamine - physiology</subject><subject>Vitamin B 12 - physiology</subject><subject>Vitamins - blood</subject><subject>Vitamins - physiology</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLxDAQhYMo67r6DxT6JPoQTZo2lwcFEW-wIMi-hzSdYKSXNUkX_Pe27rKPPg0z8505zEHonJIbSii_JYTkWDEhryS9VkQQjsUBmlOiBOaSy0M03yPH6CTGr6nNVT5DM0GVZJLN0d1H30DWu2zdGAtdMpnvstYkCJ1psINkmmzjk2nHcQqmiw7ChHwO7dicoiNnmghnu7pAq-en1eMrXr6_vD0-LLFlpUhYSKl4VZQ2t6xyZQ3GSqhMIThz0qpS1Wr6iOScFUqUxMmCg2CS1lxWQrIFutyeXYf-e4CYdOujhaYxHfRD1CNacMLzESy2oA19jAGcXgffmvCjKdGThZ4i0FMiWlL9F9qoXqCL3f2haqHei3Ypjfv77R7GHzcego7WQ2eh9gFs0nXv_zf4BdXtegE</recordid><startdate>19811201</startdate><enddate>19811201</enddate><creator>Baker, Herman</creator><creator>Frank, Oscar</creator><creator>Deangelis, Barbara</creator><creator>Feingold, Susan</creator><creator>Kaminetzky, Harold A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19811201</creationdate><title>Role of placenta in maternal-fetal vitamin transfer in humans</title><author>Baker, Herman ; Frank, Oscar ; Deangelis, Barbara ; Feingold, Susan ; Kaminetzky, Harold A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-78896b45c2c3bf5deac8eba4763f8c959d91016026349750f846e7381d68b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biotin - physiology</topic><topic>Female</topic><topic>Folic Acid - physiology</topic><topic>Humans</topic><topic>Maternal-Fetal Exchange</topic><topic>Nicotinic Acids - physiology</topic><topic>Pantothenic Acid - physiology</topic><topic>Placenta - physiology</topic><topic>Pregnancy</topic><topic>Pyridoxine - physiology</topic><topic>Riboflavin - physiology</topic><topic>Thiamine - physiology</topic><topic>Vitamin B 12 - physiology</topic><topic>Vitamins - blood</topic><topic>Vitamins - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baker, Herman</creatorcontrib><creatorcontrib>Frank, Oscar</creatorcontrib><creatorcontrib>Deangelis, Barbara</creatorcontrib><creatorcontrib>Feingold, Susan</creatorcontrib><creatorcontrib>Kaminetzky, Harold A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baker, Herman</au><au>Frank, Oscar</au><au>Deangelis, Barbara</au><au>Feingold, Susan</au><au>Kaminetzky, Harold A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of placenta in maternal-fetal vitamin transfer in humans</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1981-12-01</date><risdate>1981</risdate><volume>141</volume><issue>7</issue><spage>792</spage><epage>796</epage><pages>792-796</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Vitamins B12, B6, biotin, folate, thiamine, riboflavin, pantothenate, and nicotinate were determined in maternal and fetal blood and placental tissue of normovitaminemic and hypovitaminemic mothers who disclaimed supplemental vitamin intake during pregnancy. No biotin or pantothenate deficits were observed in the gravidas. Hypovitaminemic mothers transferred less B12, folate, and B6 to the fetus and placenta than normovitaminemic mothers. Vitamins given by mouth increased maternal, fetal, and placental levels of folate, but B6 increased only in maternal blood and the placenta; biotin and pantothenate increased only in fetal blood. Except for riboflavin, nicotinate, and pantothenate, the intramuscular administration of vitamins increased the levels of other vitamins in maternal and fetal blood and placental tissue. Results suggest that the placenta stores vitamins and that tissue vitamin receptors must be saturated before adequate transfer of vitamins to the fetus occurs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7198383</pmid><doi>10.1016/0002-9378(81)90706-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1981-12, Vol.141 (7), p.792-796 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73846062 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Biotin - physiology Female Folic Acid - physiology Humans Maternal-Fetal Exchange Nicotinic Acids - physiology Pantothenic Acid - physiology Placenta - physiology Pregnancy Pyridoxine - physiology Riboflavin - physiology Thiamine - physiology Vitamin B 12 - physiology Vitamins - blood Vitamins - physiology |
| title | Role of placenta in maternal-fetal vitamin transfer in humans |
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