Yellow fever 17D vaccine virus isolated from healthy vaccinees accumulates very few mutations

The live attenuated yellow fever (YF) vaccine strain 17D is one of the safest vaccines in use today with only 22 cases of reversion to virulence documented from over 300 million doses administered. We have isolated virus in cell culture from sera of six volunteers who received 17D vaccine and found...

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Veröffentlicht in:	Virus research 1998-05, Vol.55 (1), p.93-99
Hauptverfasser:	Xie, Hong, Cass, Alvah R, Barrett, Alan D.T
Format:	Artikel
Sprache:	eng
Schlagworte:	17D vaccine Amino Acid Sequence Amino Acid Substitution Animals Attenuation Cercopithecus aethiops Genetic Variation Humans Molecular Sequence Data Mutation Mutations Point Mutation Polymerase Chain Reaction Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Vaccinees Vaccines, Attenuated - blood Vaccines, Attenuated - genetics Vero Cells Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Vaccines - blood Viral Vaccines - genetics Yellow fever virus Yellow fever virus - genetics Yellow fever virus - immunology Yellow fever virus - isolation & purification
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