Solution Structure of the N-Terminal EGF-like Domain from Human Factor VII

Blood coagulation is initiated by Ca2+-dependent binding of coagulation factor VIIa (FVIIa) to its cofactor, tissue factor (TF). The TF:FVIIa complex activates factors IX and X, ultimately leading to the formation of thrombin and the coagulation of blood. FVII consists of an N-terminal γ-carboxyglut...

Ausführliche Beschreibung